214405-84-2Relevant academic research and scientific papers
Total synthesis of the nonadjacent bis-tetrahydrofuran Annonaceous acetogenin squamostatin-D
Marshall, James A.,Jiang, Hongjian
, p. 7066 - 7071 (2007/10/03)
A total synthesis of the Annonaceous acetogenin squamostatin-D is described. Key adjacent stereocenters were introduced through enantioselective addition of chiral oxygenated allylic tin and indium reagents to aldehyde subunits. The isolated stereocenter at C12 was constructed through addition of a functionalized organozinc reagent to an aldehyde subunit in the presence of a chiral bis-sulfonamide-titanium catalyst.
