21452-18-6

Basic information

• Product Name: 2,4-Dimethyl-N-phenyl-5-thiazolecarboxamide
• Synonyms: 2,4-Dimethyl-N-phenyl-5-thiazolecarboxamide;2,4-Dimethyl-5-(N-phenylcarbamoyl)thiazole;G-696
• CAS NO: 21452-18-6
• Molecular Formula: C₁₂H₁₂N₂OS
• Molecular Weight: 232.30148
• Mol File: 21452-18-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 141°C
• Boiling Point: 305.4°Cat760mmHg
• Flash Point: 138.5°C
• Appearance: /
• Density: 1.2052 (rough estimate)
• Vapor Pressure: 0.000825mmHg at 25°C
• Refractive Index: 1.7400 (estimate)
• PKA: 12.24±0.70(Predicted)
• Water Solubility: 2.454g/L(25 oC)
• CAS DataBase Reference: 2,4-Dimethyl-N-phenyl-5-thiazolecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dimethyl-N-phenyl-5-thiazolecarboxamide(21452-18-6)
• EPA Substance Registry System: 2,4-Dimethyl-N-phenyl-5-thiazolecarboxamide(21452-18-6)

Safety Data

• Hazardous Substances Data: 21452-18-6(Hazardous Substances Data)

Usage

General Description

2,4-Dimethyl-N-phenyl-5-thiazolecarboxamide is an organic compound with the molecular formula C13H13N3OS. It is a thiazolecarboxamide derivative, which means it contains a thiazole ring and a carboxamide group. 2,4-Dimethyl-N-phenyl-5-thiazolecarboxamide is commonly used as a fungicide and pesticide due to its ability to inhibit the growth of fungi and certain pests. It works by interfering with the metabolism of the target organisms, ultimately leading to their death. 2,4-Dimethyl-N-phenyl-5-thiazolecarboxamide is considered to be moderately toxic, and caution should be taken when handling or using it.

InChI:InChI=1/C12H12N2OS/c1-8-11(16-9(2)13-8)12(15)14-10-6-4-3-5-7-10/h3-7H,1-2H3,(H,14,15)

Upstream product

• 53137-27-2 2,4-dimethyl-thiazole-5-carboxylic acid 
• 62-53-3 aniline 

Downstream Products

• 118-69-4 2,6-dichlorotoluene 
• 931400-07-6 N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]aniline 
• 3260-88-6 1-chloro-3-methoxy-2-methylbenzene 

Relevant articles and documents

PROLYL HYDROXYLASE ANTAGONISTS

This invention relates to certain 2-[(quinolin-3-yl)carbonyl]aminoacetic acid derivatives of formula (I), where the various groups are defined herein, and which are useful in treating anemia.

Process for synthesizing benzoic acids

A nucleophilic substitution reaction on optionally substituted dihalobenzenes is carried out in the presence of an optional catalyst followed by formation of and subsequent carboxylation of a Grignard reaction intermediate. In particular the present invention provides a process leading to optionally substituted hydroxybenzoic, alkanoyloxybenzoic, formyloxybenzoic and alkoxybenzoic acids from 1-substituted 2,6-dihalobenzenes. The invention also provides a process for the direct formation of an acyl chloride from a Grignard reagent by quenching with phosgene.

Process for synthesizing benzoic acids

Nucleophilic substitution reactions on halobenzenes are carried out in the presence of catalysts. In particular the present invention provides a process leading to optionally substituted hydroxybenzoic and alkoxybenzoic acids and optionally substituted hydroxybenzonitriles and alkoxybenzonitriles from substituted 2,6-dihalobenzenes.