214535-77-0Relevant articles and documents
Chemoselective Removal of Dimeric 1,3-Diol Impurities Generated from Methyl Grignard Addition onto Esters
Tucker, John L.,Couturier, Michel,Leeman, Kyle R.,Hinderaker, Matthew P.,Andresen, Brian M.
, p. 929 - 932 (2003)
In two separate cases, we have found that 1,3-diol dimeric impurities were common byproducts generated from the methyl Grignard addition onto esters to form the corresponding tertiary alcohols. These impurities proved difficult to purge by recrystallization as they tended to cocrystallize with the desired product. To avoid the necessity of chromatography, we developed a practical procedure for the chemoselective removal of these 1,3-diol impurities from crude tertiary alcohol by simply performing the recrystallization in the presence of phenylboronic acid. This straightforward method proved equally successful for two cases studied, and the procedure was later demonstrated on a multikilogram scale.
Nicotinamide derivatives
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, (2008/06/13)
A compound of formula (I) wherein m, n, o, p, q, r, A, B, D, E, R1, R2,R3, R4, R5, R6, R7and R8are as defined in the description, useful in the treatment of respiratory, allergic, rheumatoid, body weight regulation, inflammatory and central nervous system disorders such as asthma, chronic obstructive pulmonary disease, adult respiratory diseases syndrome, shock, fibrosis, pulmonary hypersensitivity, allergic rhinitis, atopic dermatitis, psoriasis, weight control, rheumatoid arthritis, cachexia, crohn's disease, ulcerative colitis, arthritic conditions and other inflammatory diseases, depression, multi-infarct dementia and AIDS.
