214554-25-3Relevant academic research and scientific papers
Fluorinated linkers for monitoring solid-phase synthesis using gel- phase 19F NMR spectroscopy
Svensson, Anette,Bergquist, Karl-Erik,Fex, Tomas,Kihlberg, Jan
, p. 7193 - 7196 (2007/10/03)
Three fluorinated linkers which are analogues of linkers commonly used in solid-phase peptide synthesis have been prepared. Using 19F NMR spectroscopy, the fluorine atom of the linker allowed monitoring of several transformations in the solid-phase synthesis of a peptoid having a coumarin moiety. Especially, attachment of the linker to the solid phase, coupling of the first building block to the linker and cleavage of the product were efficiently monitored and optimised.
