21458-36-6Relevant academic research and scientific papers
Silica sulfuric acid as a reusable catalyst for the conversion of ketones into amides by a Schmidt reaction under solvent-free conditions
Eshghi, Hossein,Hassankhani, Asadollah,Mosaddegh, Elaheh
, p. 218 - 219 (2007/10/03)
Silica sulfuric acid is a highly efficient reagent for the conversion of a variety of ketones into the corresponding amides by a Schmidt reaction under solvent-free conditions. Cyclic, aliphatic and aromatic ketones with electron-donating or withdrawing substituents may be converted easily in excellent yield. The major advantages of this method are: operational simplicity, the ready availability of the reagent, selectivity, general applicability, mild reaction conditions, short reaction times and high yields. The recovered catalyst could be used in new attempts without any purification.
CONJUGATE ADDITION OF ORGANOCOPPER REAGENTS TO N-TOSYLATED α, β-UNSATURATED AMIDES
Nagashima, Hideo,Ozaki, Nobuyasu,Washiyama, Masayoshi,Itoh, Kenji
, p. 657 - 660 (2007/10/02)
N-Tosylated α, β-unsaturated amides and lactams undergo facile conjugate addition with R2CuLi or RMgX/CuI (cat.).Stereoselective synthesis of trans-β,γ-dialkyl-γ-lactams can be achieved by this procedure.The resulting N-tosylamide moiety is further transformed to alcohol and several carbonyl compounds by way of reduction or nucleophillic displacement.
