214614-59-2Relevant academic research and scientific papers
Occupying a flat subpocket in a tRNA-modifying enzyme with ordered or disordered side chains: Favorable or unfavorable for binding?
Neeb, Manuel,Hohn, Christoph,Ehrmann, Frederik Rainer,H?rtsch, Adrian,Heine, Andreas,Diederich, Fran?ois,Klebe, Gerhard
, p. 4900 - 4910 (2016)
Small-molecule ligands binding with partial disorder or enhanced residual mobility are usually assumed as unfavorable with respect to their binding properties. Considering thermodynamics, disorder or residual mobility is entropically favorable and contrib
Carboxylic acid ester derivative and medical uses thereof
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Paragraph 0150; 0203-0207, (2019/07/04)
The invention relates to a compound represented by a general formula (I) or a stereoisomer, a hydrate, a metabolite, a solvate, a pharmaceutically acceptable salt, an eutectic or a prodrug thereof, and a preparation method thereof, and applications in pre
Structure-activity relationship studies of the chromosome segregation inhibitor, Incentrom A
Lee, Hee-Yoon,Jung, Yongsik,Kim, Wonyeob,Kim, Jin Hee,Suh, Min-Soo,Shin, Seung Koo,Yoon, Hye-Joo
scheme or table, p. 4670 - 4674 (2009/04/08)
A series of Incentrom A analogs that inhibit the chromosome segregation process in yeast were synthesized and tested for their effects on chromosome stability and cell proliferation. Pharmacophore and structure-activity relationship of Incentrom A for the anti-yeast activity were established.
