5140-03-4

Usage

Uses

Used in Chemical Synthesis:
1,4-Benzenediethanol is used as a building block for the synthesis of various organic compounds, including polymers, resins, and plasticizers. Its presence in these materials contributes to their structural integrity and functional properties.
Used in Epoxy Resin Production:
1,4-Benzenediethanol is used as a crosslinking agent in the production of epoxy resins. These resins are widely employed in adhesives, coatings, and composites, enhancing their durability and performance.
Used in Cosmetics, Pharmaceuticals, and Personal Care Products:
1,4-Benzenediethanol is used as a preservative in cosmetics, pharmaceuticals, and personal care products due to its antimicrobial properties. It helps maintain the quality and safety of these products by preventing the growth of harmful microorganisms.

Upstream product

• 36076-26-3 diethyl 2,2'-(1,4-phenylene)diacetate 
• 105-05-5 1,4-diethylbenzene 
• 7325-46-4 1,4-phenylenediacetic acid 
• 589-29-7 p-xylylene glycol 
• 39246-00-9 p-phenylenediacetaldehyde 
• 36076-25-2 (4-methoxycarbonylmethylphenyl)acetic acid methyl ester 
• 622-75-3 1,4-phenylenediacetonitrile 
• 95-71-6 2-methylbenzene-1,4-diol 

Downstream Products

• 105-06-6 1,4-Divinylbenzene 
• 4542-72-7 1,4-bis-(2-bromoethyl)benzene 
• 7379-84-2 1,4-bis(2-chloroethyl)benzene 
• 118174-91-7 1,4-bis-(2-ethoxycarbonyloxy-ethyl)-benzene 
• 157860-90-7 1,4-Bis<2-(trifluormethylsulfonyloxy)ethyl>benzol 
• 39246-00-9 p-phenylenediacetaldehyde 
• 874338-61-1 1-phenyl-4-[4-(2-hydroxy-4-phenyl-3-butynyl)phenyl]but-3-yn-2-ol 
• 1257583-45-1 1,4-bis(2-((cis-5-methyl-r-2-phenyl-1,3-dioxan-5-yl)methanoyloxy)ethyl)benzene 
• 1352790-40-9 C₁₀H₁₂I₂O₂ 
• 1352790-41-0 2,2'-(2,5-diiodo-1,4-phenylene)diacetic acid 
• 94112-70-6 1,4-bis-(2-acetoxy-ethyl)-benzene 

Relevant academic research and scientific papers

FUNCTIONALIZED LONG-CHAIN HYDROCARBON MONO- AND DI-CARBOXYLIC ACIDS AND THEIR USE FOR THE PREVENTION OR TREATMENT OF DISEASE

This invention provides compounds of Formulae (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (IK), (IL), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof. This invention further provides methods for treating a disease, including but not limited to, liver disease or an abnormal liver condition; cancer (such as hepatocellular carcinoma or cholangiocarcinoma); a malignant or benign tumor of the lung, liver, gall bladder, bile duct or digestive tract; an intra- or extra-hepatic bile duct disease; a disorder of lipoprotein; a lipid-and-metabolic disorder; cirrhosis; fibrosis; a disorder of glucose metabolism; a cardiovascular or related vascular disorder; a disease resulting from steatosis, fibrosis, or cirrhosis; a disease associated with increased inflammation (such as hepatic inflammation or pulmonary inflammation); hepatocyte ballooning; a peroxisome proliferator activated receptor-associated disorder; an ATP citrate lyase disorder; an acetyl-coenzyme A carboxylase disorder; obesity; pancreatitis; or renal disease.

SULFONIMIDAMIDE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY

In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: (Formula AA) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.

SULFONAMIDE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of Formula (I) or (II): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY

In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured.The variables shown in Formula AA are as defined in the claims. The compounds of formula AA are NLRP3 activity modulators and, as such, can be used in the treatment of metabolic disorders (e.g. Type 2 diabetes, atherosclerosis, obesity or gout), a disease of the central nervous system (e.g. Alzheimer's disease, multiple sclerosis, Amyotrophic Lateral Sclerosis or Parkinson's disease), lung disease (e.g. asthma, COPD or pulmonary idiopathic fibrosis), liver disease (e.g. NASH syndrome, viral hepatitis or cirrhosis), pancreatic disease (e.g. acute pancreatitis or chronic pancreatitis), kidney disease (e.g. acute kidney injury or chronic kidney injury), intestinal disease (e.g. Crohn's disease or Ulcerative Colitis), skin disease (e.g. psoriasis), musculoskeletal disease (e.g. scleroderma), a vessel disorder (e.g. giant cell arteritis), a disorder of the bones (e.g. osteoarthritis, osteoporosis or osteopetrosis disorders), eye disease (e.g. glaucoma or macular degeneration), a disease caused by viral infection (e.g. HIV or AIDS), an autoimmune disease (e.g. Rheumatoid Arthritis, Systemic Lupus Erythematosus or Autoimmune Thyroiditis), cancer or aging.

Iron-Catalyzed β-Alkylation of Alcohols

β-Branched alkylated alcohols have been prepared in good yields using a double-hydrogen autotransfer strategy in the presence of our diaminocyclopentadienone iron tricarbonyl complex Fe1. The alkylation of some 2-arylethanol derivatives was successfully addressed with benzylic alcohols and methanol as alkylating reagents under mild conditions. Deuterium labeling experiments suggested that both alcohols (2-arylethanol and either methanol or benzyl alcohol) served as hydrogen donors in this cascade process.

Occupying a flat subpocket in a tRNA-modifying enzyme with ordered or disordered side chains: Favorable or unfavorable for binding?

Small-molecule ligands binding with partial disorder or enhanced residual mobility are usually assumed as unfavorable with respect to their binding properties. Considering thermodynamics, disorder or residual mobility is entropically favorable and contrib

Anti-cancer compositions and methods

Anti-cancer compositions and methods are described including one or more compounds having the structural formula I: where R is phenyl, where R1 is (CH2)n—Se—C(═NH)—NH2, where R2 is (CH2)n—Se—C(═NH)—NH

Synthesis of new cores and their use in the preparation of polyester dendrimers

Six dendrimer and dendron cores terminated by hydroxyl groups that are neither phenolic nor cleavable by hydrogenolysis have been prepared in a consistent one-pot manner from terminal allyl groups by reduction of the product of reductive ozonolysis. Some of the terminal allyl derivatives are new and others have been prepared by new methods. The well-known O-benzylidene derivative of 2,2′-bis(hydroxymethyl)propanoic acid was shown to be the cis-stereoisomer. A new AB3-type anhydride, tris(benzyloxymethyl) acetic anhydride has been prepared. It was demonstrated that these cores and dendrons could be assembled into first and second generation homo- and mixed polyester dendrimers.

Synthesis and characterization of a novel iNOS/Akt inhibitor Se,Se′-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)-against colon cancer

Our studies demonstrate that substitution of sulfur with selenium in known iNOS inhibitor increases the compound's potency by several folds in variety of different cancers cell lines tested. Hence, this approach may be used as a strategy to increase the e

Synthesis of naphthalenes and 2-naphthols by the electrophilic cyclization of alkynes

A wide variety of substituted naphthalenes are readily prepared regioselectively under mild reaction conditions by the 6-endo-dig electrophilic cyclization of appropriate arene-containing propargylic alcohols by IC1, I 2, Br2, NBS, and PhSeBr. 3-Iodo-2-naphthols have also been prepared in excellent yields by the cyclization of analogous 1-aryl-3-alkyn-2-ones. This methodology readily accommodates various functional groups and has been successfully extended to the synthesis of substituted carbazoles and dibenzothiophenes.