214677-45-9Relevant academic research and scientific papers
Design and synthesis of diaminopyrrolidinone inhibitors of human osteoclast cathepsin K
Duffy, Kevin J.,Ridgers, Lance H.,Desjarlais, Renee L.,Tomaszek, Thaddeus A.,Bossard, Mary J.,Thompson, Scott K.,Keenan, Richard M.,Veber, Daniel F.
, p. 1907 - 1910 (1999)
The structure-based design and synthesis of lactam-constrained azapeptide inhibitors of human cathepsin K are described. Enhanced stability to proteolytic cleavage over acyclic analogues is discussed.
PROTEASE INHIBITORS
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Page 56, (2010/02/09)
A monoacyl semicarbazide of the general formula (I): (I), or a pharmaceutically acceptable salt or ester thereof, is capable of selectively inhibiting dipeptidyl-peptidase I (DPP-I), also known as cathepsin C. A compound of the invention is useful as an active substance for the treatment of inflammation, type 2 diabetes, asthma, severe influenza, respiratory syncytial virus infection, CD8 T cell inhibition, inflammatory bowel diseases, psoriasis, atopic dermatitis, Papillon Lefevre syndrome, Haim Munk syndrome, gum disease, periodontitis, rheumatoid arthritis, Huntington’s disease, Chaga’s disease, Alzheimer’s disease, sepsis or for application in target cell apoptosis.
