Bioorganic and Medicinal Chemistry Letters p. 1907 - 1910 (1999)
Update date:2022-08-05
Topics:
Duffy, Kevin J.
Ridgers, Lance H.
Desjarlais, Renee L.
Tomaszek, Thaddeus A.
Bossard, Mary J.
Thompson, Scott K.
Keenan, Richard M.
Veber, Daniel F.
The structure-based design and synthesis of lactam-constrained azapeptide inhibitors of human cathepsin K are described. Enhanced stability to proteolytic cleavage over acyclic analogues is discussed.
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