Design and synthesis of diaminopyrrolidinone inhibitors of human osteoclast cathepsin K

DOI: 10.1016/S0960-894X(99)00322-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1907 - 1910 (1999)

Update date:2022-08-05

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Authors:

Duffy, Kevin J.

Ridgers, Lance H.

Desjarlais, Renee L.

Tomaszek, Thaddeus A.

Bossard, Mary J.

Thompson, Scott K.

Keenan, Richard M.

Veber, Daniel F.

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Article abstract of DOI:10.1016/S0960-894X(99)00322-4

The structure-based design and synthesis of lactam-constrained azapeptide inhibitors of human cathepsin K are described. Enhanced stability to proteolytic cleavage over acyclic analogues is discussed.

Full text of DOI:10.1016/S0960-894X(99)00322-4

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