214677-49-3

Upstream product

• 190142-10-0 (1S)-1-(benzyloxycarbonyl)amino-1-(4-carboethoxythiazol-2-yl)-3-methylbutane 
• 111946-80-6 N-t-Butoxycarbonyl-(S)-leucinethioamide 
• 4801-79-0 N-benzyloxycarbonyl-L-leucinamide 

Relevant academic research and scientific papers

Azotides as Modular Peptide-Based Ligands for Asymmetric Lewis Acid Catalysis

Synthesis of azotides and evaluation of these as ligands for enantioselective Lewis acid catalysis is reported. The ligands were readily prepared from the chiral pool of amino acids and perform well in the cobalt(II)-catalyzed formation of asymmetric hete

Protease inhibitors

The present invention provides compounds of formula (I) which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia or malignancy; and metabolic bone disease therewith.

Design and synthesis of diaminopyrrolidinone inhibitors of human osteoclast cathepsin K

The structure-based design and synthesis of lactam-constrained azapeptide inhibitors of human cathepsin K are described. Enhanced stability to proteolytic cleavage over acyclic analogues is discussed.