21469-29-4

Upstream product

• 143-07-7 lauric acid 
• 51-67-2 tyrosamine 

Downstream Products

• 914491-26-2 C₂₀H₃₁Br₂NO₂ 

Relevant academic research and scientific papers

Phosphite sodium salt modified amphipathic phosphorus-containing crown macromolecule nano micelle and preparation and application thereof

The invention relates to a phosphite sodium salt modified amphipathic phosphorus-containing crown macromolecule nano micelle and a preparation method and application thereof. The preparation method is simple, the controllability of the reaction process is high, and the operation is easy. Compared with the reported polyamide - amine type crown macromolecule nano-micelle, the nano material has higher encapsulation efficiency, loading rate and better anti-inflammatory effect, can effectively improve the treatment effect of the hydrophobic drug, and has good application prospects.

Potent Anticancer Efficacy of First-In-Class CuII and AuIII Metaled Phosphorus Dendrons with Distinct Cell Death Pathways

First-in-class CuII and AuIII metaled phosphorus dendrons were synthesized and showed significant antiproliferative activity against several aggressive breast cancer cell lines. The data suggest that the cytotoxicity increases with reducing length of the alkyl chains, whereas the replacement of CuII with AuIII considerably increases the antiproliferative activity of metaled phosphorus dendrons. Very interestingly, we found that the cell death pathway is related to the nature of the metal complexed by the plain dendrons. CuII metaled dendrons showed a potent caspase-independent cell death pathway, whereas AuIII metaled dendrons displayed a caspase-dependent apoptotic pathway. The complexation of plain dendrons with AuIII increased the cellular lethality versus dendrons with CuII and promoted the translocation of Bax into the mitochondria and the release of Cytochrome C (Cyto C).

Phosphor-containing crown macromolecular hybrid nanometer material and preparation method and application thereof

The invention relates to a phosphor-containing crown macromolecular hybrid nanometer material and a preparation method and application thereof. The phosphor-containing crown macromolecular hybrid nanometer material is characterized in that phosphonitrilic chloride trimer is used as a core to synthesize novel phosphor-containing crown macromolecules by a layered modifying method, the surface is modified with pyridine, the novel phosphor-containing crown macromolecule of which the surface contains metal ion chelating sites is obtained, and the copper ions and gold ions are directly complexed, soas to form the hybrid nanometer material for preparing anti-tumor drugs. The phosphor-containing crown macromolecular hybrid nanometer material has the advantages that the raw materials are commercialized, the molecular weight of the prepared phosphor-containing crown macromolecule is uniform, the preparation method is simple, the controllability of reaction process is high, the operation is easy, and a plurality of metal ion chelating sites is contained; the prepared hybrid nanometer material can be applied to the anti-tumor study, and the good application prospect is realized.

Antiplasmodial metabolites isolated from the marine octocoral Muricea austera

Bioassay-guided fractionation of the MeOH extract from the octocoral Muricea austera collected in the Pacific coast of Panama led to the isolation of eight compounds, including three tyramine derivatives (1-3), two steroidal pregnane glycosides (4, 5), and three sesquiterpenoids (6-8). Compounds 2-5 are new natural products, and their structures were determined on the basis of their spectroscopic data (HRMS, 1D and 2D NMR, and CD studies). The antiprotozoal activities of the natural compounds 1-8 as well as those of a series of synthetic glycosides (11-22) and tyramine derivatives (23-35) were evaluated in vitro against a drug-resistant Plasmodium falciparum and intracellular form of Trypanosoma cruzi.