214701-33-4

Basic information

• Product Name: 5-BROMO-2-(2-METHYL-1,3-DIOXOLAN-2-YL)PYRIDINE
• Synonyms: 5-BROMO-2-(2-METHYL-1,3-DIOXOLAN-2-YL)PYRIDINE
• CAS NO: 214701-33-4
• Molecular Formula: C₉H₁₀BrNO₂
• Molecular Weight: 244.0852
• Mol File: 214701-33-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 294.405°C at 760 mmHg
• Flash Point: 131.852°C
• Appearance: /
• Density: 1.499g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-BROMO-2-(2-METHYL-1,3-DIOXOLAN-2-YL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-(2-METHYL-1,3-DIOXOLAN-2-YL)PYRIDINE(214701-33-4)
• EPA Substance Registry System: 5-BROMO-2-(2-METHYL-1,3-DIOXOLAN-2-YL)PYRIDINE(214701-33-4)

Safety Data

• Hazardous Substances Data: 214701-33-4(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-(2-methyl-1,3-dioxolan-2-yl)pyridine is a chemical substance with the molecular formula C8H8BrNO2. It is a brominated pyridine derivative and contains a dioxolane ring. 5-BROMO-2-(2-METHYL-1,3-DIOXOLAN-2-YL)PYRIDINE is used as a building block in organic synthesis and can be employed in the pharmaceutical and agrochemical industries. Its unique structure and reactivity make it a valuable intermediate in the preparation of various compounds with potential applications in drug discovery and development. Additionally, it may have potential uses in research and development for new materials and chemical technologies.

InChI:InChI=1/C9H10BrNO2/c1-9(12-4-5-13-9)8-3-2-7(10)6-11-8/h2-3,6H,4-5H2,1H3

Upstream product

• 107-21-1 ethylene glycol 
• 214701-49-2 1-(5-bromopyridin-2-yl)ethanone 
• 111770-80-0 3-bromo-6-(trimethylsilylethynyl)pyridine 

Downstream Products

• 1044210-44-7 C₁₆H₁₅F₃N₂O₂ 
• 856014-24-9 2-amino-4-(3-bromophenyl)-6-[2-(4-morpholinyl)-5-pyridyl]nicotinonitrile 

Relevant articles and documents

Theramutein modulators

This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and activators of endogenous protein variants, encoded by genes which have mutated, which variants often arise or are at least first identified as having arisen following exposure to a chemical agent which is known to be an inhibitor or activator of the corresponding unmutated endogenous protein.

5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d] pyrimidin-4-ylamine: Structure-activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors

4-Amino-5,7-disubstituted pyridopyrimidines are potent, non-nucleoside inhibitors of adenosine kinase (AK). We recently identified a potent, orally efficacious analog, 4 containing a 7-pyridylmorpholine substituted ring system as the key structural element of this template. In this report, we disclose the pharmacologic effects of five- and six-membered heterocyclic ring replacements for the pyridine ring in 4. These replacements were found to have interesting effects on in vivo efficacy and genotoxicity as well as in vitro potency. We discovered that the nitrogen in the heterocyclic ring at C(7) is important for the modulation of mutagenic side effects (Ames assay).