21472-89-9 Usage
Uses
1-Azabicyclo[2.2.1]heptan-3-one (CAS# 21472-89-9) can be used in the preparation of spirocyclic quinuclidinyl-Δ2-isoxazolines as neuronal nicotinic acetylcholine receptor agonists. It can also be used in the preparation of isoquinoline derivatives as progranulin modulators useful in treatment of progranulin-associated disorders. Useful in the preparation of N-pyridinyl carboxamides as cyclin-dependent kinase inhibitors. Useful in the preparation of glucosylceramide synthase inhibitors for treatment of metabolic diseases, such as lysosomal storage diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 21472-89-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,4,7 and 2 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 21472-89:
(7*2)+(6*1)+(5*4)+(4*7)+(3*2)+(2*8)+(1*9)=99
99 % 10 = 9
So 21472-89-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H9NO/c8-6-4-7-2-1-5(6)3-7/h5H,1-4H2
21472-89-9Relevant articles and documents
PROGRANULIN MODULATORS AND METHODS OF USING THE SAME
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Paragraph 0967; 0972-0973, (2020/12/30)
Provided herein are compounds that modulate progranulin and methods of using the compounds in progranulin-associated disorders, such as Frontotemporal dementia (FTD).
Glucosylceramide synthase inhibitors
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Page/Page column 53, (2015/09/28)
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
Oxadiazoles useful in the treatment of senile dementia
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, (2008/06/13)
A class of novel oxadiazoles, substituted on one of the ring carbon atoms with a non-aromatic azacyclic or azabicyclic ring, and substituted on the other ring carbon atom with a substituent of low lipophilicity; are potent muscarinic agonists, and have good CNS penetrability. The compounds are therefore useful in the treatment of neurological and mental illnesses.
