125059-55-4Relevant academic research and scientific papers
Synthesis of Azabicyclic Pyrazine Derivatives as Muscarinic Agonists and the Preparation of a Chloropyrazine Analogue with Functional Selectivity at Sub-types of the Muscarinic Receptor
Baker, Raymond,Street, Leslie J.,Reeve, Austin J.,Saunders, John
, p. 760 - 762 (1991)
The synthesis of quinuclidine and azanorbornyl pyrazine derivatives has yielded highly potent and efficacious muscarinic agonists; chloro-substitution in the pyrazine ring of the quinuclidine analogue resulted in the formation of a derivative with both enantiomers displaying partial agonist character but, more importantly, functional selectivity at the M1, M2 and M3 sub-types of the muscarinic receptor.
PYRAZINES, PYRIMIDINES AND PYRIDAZINES USEFUL IN THE TREATMENT OF SENILE DEMENTIA
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, (2008/06/13)
The present invention provides pyrazines, pyridazines or pyrimidines, or salts or prodrugs thereof, substituted on one of the ring carbon atoms thereof with a non-aromatic azacyclic or azabicyclic ring system; and independently substituted on each of the other ring carbon atoms with a substituent of low lipophilicity or a hydrocarbon substituent; which compounds stimulate central muscarinic acetylcholine receptors and therefore are useful in the treatment of neurological and mental illnesses.
