21474-92-0

Upstream product

• 117442-74-7 (Z)-1-ethoxy-3-methyl-1-trimethylsiloxy-1-butene 
• 68-12-2 N,N-dimethyl-formamide 
• 108-64-5 Ethyl isovalerate 
• 109-94-4 formic acid ethyl ester 
• 107-31-3 Methyl formate 
• 87884-39-7 2-hydroxymethyl-3-methyl-butyric acid ethyl ester 
• 609-12-1 ethyl 2-bromoisovalerate 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 127870-28-4 2-[1-[(S)-1-((R)-1-Acetylamino-2-phenyl-ethylcarbamoyl)-2-phenyl-ethylamino]-meth-(E)-ylidene]-3-methyl-butyric acid ethyl ester 
• 127870-34-2 2-[1-((S)-1-Acetylamino-2-phenyl-ethylamino)-meth-(E)-ylidene]-3-methyl-butyric acid ethyl ester 
• 607714-45-4 2-(benzyloxyimino-methyl)-3-methyl-butyric acid ethyl ester 
• 1058157-97-3 (S)-2-(4-cyclohexyl-phenoxymethyl)-6-isopropyl-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one 
• 101575-56-8 4-isopropyl-3-(4-nitro-benzoyloxy)-pyrrole-2-carboxylic acid ethyl ester 
• 127870-30-8 2-{[(R)-1-((S)-1-Acetylamino-2-phenyl-ethylcarbamoyl)-2-phenyl-ethylamino]-methyl}-3-methyl-butyric acid ethyl ester; hydrochloride 
• 90031-34-8 2-Phenethylaminomethyl-isovaleriansaeure-ethylester 
• 607715-29-7 (R)-2-[(Benzyloxy-formyl-amino)-methyl]-N-((S)-1-dimethylcarbamoyl-2,2-dimethyl-propyl)-3-methyl-butyramide 
• 607715-08-2 (R)-2-(Benzyloxyamino-methyl)-N-((S)-1-dimethylcarbamoyl-2,2-dimethyl-propyl)-3-methyl-butyramide 
• 607714-87-4 2-(benzyloxyimino-methyl)-N-(1-dimethylcarbamoyl-2,2-dimethyl-propyl)-3-methyl-butyramide 
• 607714-66-9 2-(benzyloxyimino-methyl)-3-methyl-butyric acid 

Relevant academic research and scientific papers

Insertion of Alkylidene Carbenes into B-H Bonds

We have developed a protocol for insertion of alkylidene carbenes into the B-H bonds of amine-borane adducts, enabling, for the first time, the construction of C(sp2)-B bonds by means of carbene-insertion reactions. Various acyclic and cyclic alkenyl borane-amine adducts were prepared from readily accessible starting materials in good to high yields and were subsequently subjected to a diverse array of functional group transformations. The unprecedented spiro B-N heterocycles prepared in this study have potential utility as building blocks for the synthesis of pharmaceuticals. Preliminary mechanistic studies suggest that insertion of the alkylidene carbenes into the B-H bonds of the amine-borane adducts proceeds via a concerted process involving a three-membered-ring transition state.

Lewis base catalyzed asymmetric hydrosilylation of α-substituted β-enamino esters: Facile access to enantioenriched β2-amino esters via dynamic kinetic resolution

A chiral Lewis base organocatalyzed asymmetric hydrosilylation of α-substituted β-enamino esters is presented. The reactions proceeded through dynamic kinetic resolution to afford various enantioenriched β2-amino esters with high yields (up to

Diastereospecific nazarov cyclization of fully substituted dienones: Generation of vicinal all-carbon-atom quaternary stereocenters

No vacancy: Fully substituted dienones that are highly polarized by a vinylogous carbonate group were found to undergo a remarkably rapid and diastereospecific Nazarov cyclization that led to cyclopentenones with vicinal all-carbon-atom quaternary centers (see example; SEM=2-(trimethylsilyl) ethoxymethyl, Tf=trifluoromethanesulfonyl). Copyright

SUBSTITUTED PHENOXYMETHYL DIHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF

The present invention relates to a series of substituted phenoxymethyl dihydro oxazolopyrimidinones of formula (I) defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of this invent

SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF

The present invention relates to a series of substituted dihydro and tetrahydro oxazolopyrimidinones, specifically, to a series of 2-substituted-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-ones and 2-substituted-2,3,5,6-tetra-hydro-oxazolo[3,2-a]pyrimidin-7-ones of formula (I): Wherein p, n, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of this invention are modulators of metabotropic glutamate receptors (mGluR), particularly, mGluR2 receptor. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic neurodegenerative conditions, psychoses, convulsions, anxiety, depression, migraine, pain, sleep disorders and emesis.

[1,2,4]THIADIAZINE 1,1-DIOXIDE COMPOUNDS

The invention is directed to [1,2,4]thiadiazine 1,1-dioxide compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.

Structure-activity relationships of the peptide deformylase inhibitor BB-3497: Modification of the methylene spacer and the P1′ side chain

Structural modifications to the peptide deformylase inhibitor BB-3497 are described. In this paper, we describe the initial SAR around this lead for modifications to the methylene spacer and the P1′ side chain. Enzyme inhibition and antibacterial activity data revealed that the optimum distance between the N-formyl hydroxylamine metal binding group and the P1′ side chain is one unsubstituted methylene unit. Additionally, lipophilic P1′ side chains that closely mimic the methionine residue in the substrate provided compounds with the best microbiological profile.

Vilsmeier Formylation of O-Silylated Enolates of Carboxylic Esters. A New Method for the Synthesis of α-Formylcarboxylic Esters

The Vilsmeier formylation of ketene O-alkyl O'-silyl acetals (O-silylated enolates of carboxylic esters) provides α-formylcarboxylic esters in moderate yields.