214784-13-1Relevant academic research and scientific papers
DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY
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Page/Page column 99, (2008/12/04)
The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.
Inhibition of Glycosidases by Lactam Oximes: Influence of the Aglycon in Disaccharide Analogues
Vonhoff, Stefan,Heightman, Tom D.,Vasella, Andrea
, p. 1710 - 1725 (2007/10/03)
The influence of a substituent at the hydroximo function of the lactam analogue 1 on the inhibition of β- and α-glucosidases is evaluated. In contrast to 1, the O-alkyl oximes 5, 6, 9, and 10 are selective inhibitors of β-glucosidases. Alkylation of the D
