21483-64-7

Basic information

• Product Name: tert-butyl (2-broMothiophen-3-yl)carbaMate
• Synonyms: N-(2-Bromo-3-thienyl)carbamic acid 1,1-dimethylethyl ester;N-Boc-3-amino-2-bromothiophene;tert-butyl (2-broMothiophen-3-yl)carbaMate;2-Bromo-3-thiophenecarbamic acid (tert-butyl ester);3-(Boc-amino)-2-bromothiophene
• CAS NO: 21483-64-7
• Molecular Formula: C₉H₁₂BrNO₂S
• Molecular Weight: 278
• EINECS: -0
• Mol File: 21483-64-7.mol
• Article Data: 9

Chemical Properties

• Melting Point: 65-70°C
• Boiling Point: 276.4±25.0 °C(Predicted)
• Appearance: /
• Density: 1.510±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.77±0.70(Predicted)
• CAS DataBase Reference: tert-butyl (2-broMothiophen-3-yl)carbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (2-broMothiophen-3-yl)carbaMate(21483-64-7)
• EPA Substance Registry System: tert-butyl (2-broMothiophen-3-yl)carbaMate(21483-64-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 21483-64-7(Hazardous Substances Data)

Usage

Description

tert-butyl (2-broMothiophen-3-yl)carbaMate is an organic compound with the molecular formula C10H12BrNO2S. It is characterized by the presence of a tert-butyl group, a bromo-thiophene ring, and a carbamate functional group. tert-butyl (2-broMothiophen-3-yl)carbaMate is of interest due to its potential applications in various fields, particularly in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
tert-butyl (2-broMothiophen-3-yl)carbaMate is used as a key intermediate in the synthesis of thienopyrazines, which are known to be inhibitors of IRAK4 activity. IRAK4 (interleukin-1 receptor-associated kinase 4) is a crucial enzyme involved in the regulation of inflammatory responses and immune system signaling. Inhibition of IRAK4 can potentially lead to the development of novel therapeutics for the treatment of various inflammatory and autoimmune diseases.
Used in Chemical Synthesis:
In the chemical industry, tert-butyl (2-broMothiophen-3-yl)carbaMate can be utilized as a building block for the creation of more complex molecules with diverse applications. Its unique structural features, including the bromo-thiophene ring and carbamate group, make it a valuable component in the synthesis of various organic compounds, potentially leading to new materials with specific properties and functions.
It is important to note that the specific applications and uses of tert-butyl (2-broMothiophen-3-yl)carbaMate may vary depending on the context and the requirements of the industry it is being used in. Further research and development are necessary to fully understand its potential and optimize its applications.

Upstream product

• 24287-95-4 2-bromothiophene-3-carboxylic acid 
• 75-65-0 tert-butyl alcohol 
• 19228-91-2 tert-butyl 3-thienylcarbamate 

Downstream Products

• 40826-38-8 Dithieno<3,2-b;2',3'-d>pyridine 
• 335075-94-0 tert-Butyl N-((E)-3-phenylprop-2-enyl)(2-bromo-3-thienyl)carbamate 

Relevant articles and documents

Substituted 1,2,3,4-tetrahydrobenzo[C][2,7] naphthyridines and derivatives thereof as kinase inhibitors

The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

PYRAZOLOPYRIMIDINE INHIBITORS OF IRAK4 ACTIVITY

The present invention relates to pyrazolopyrimidine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.