214837-31-7Relevant academic research and scientific papers
Solid- and solution-phase synthesis of highly-substituted-pyrrolidine libraries
Steger,Hubschwerlen,Schmid
, p. 2537 - 2540 (2007/10/03)
Starting from a complex bicyclic β-lactam scaffold we have demonstrated the possible production of libraries of a new class of drug-like, highly substituted pyrrolidines. The choice of the type of substitution was made by optimizing various synthetic rout
Structure-based design of β-lactamase inhibitors. 1. Synthesis and evaluation of bridged monobactams
Heinze-Krauss, Ingrid,Angehrn, Peter,Charnas, Robert L.,Gubernator, Klaus,Gutknecht, Eva-Maria,Hubschwerlen, Christian,Kania, Malgosia,Oefner, Christian,Page, Malcolm G. P.,Sogabe, Satoshi,Specklin, Jean-Luc,Winkler, Fritz
, p. 3961 - 3971 (2007/10/03)
Bridged monobactams are novel, potent, mechanism-based inhibitors of class C β-lactamases, designed using X-ray crystal structures of the enzymes. They stabilize the acyl-enzyme intermediate by blocking access of water to the enzyme-inhibitor ester bond.
