214837-33-9

Upstream product

• 214837-07-7 (3S,4S)-<1-(3,4-dimethoxybenzyl)-2-oxo-4-<(R)-2-oxo-1,3-dioxololan-3-yl>azetidin-3-yl>carbamic acid benzyl ester 
• 145574-13-6 benzyl (1S,4S,5S)-6-(3,4-dimethoxybenzyl)-4-hydroxy-7-oxo-2,6-diazabicyclo<3.2.0>heptane-2-carboxylate 
• 145574-39-6 benzyl (1S,4S,5S)-4-hydroxy-7-oxo-2,6-diazabicyclo<3.2.0>heptane-2-carboxylate 
• 110-87-2 3,4-dihydro-2H-pyran 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 214837-31-7 (1S,4S,5S)-2-(benzyloxycarbonyl)-4-(tetrahydropyran-2-yloxy)-2,6-diazabicyclo<3.2.0>heptan-7-one 

Downstream Products

• 214837-34-0 benzyl (1S,4S,5S)-6-(tert-butyldimethylsilanyl)-7-oxo-4-<(trifluoromethyl)sulfonyloxy>-2,6-diazabicyclo<3.2.0>heptane-2-carboxylate 
• 214837-36-2 benzyl (1S,5R)-6-(tert-butyldimethylsilanyl)-4-(carbamoylmethylene)-7-oxo-2,6-diazabicyclo<3.2.0>heptane-2-carboxylate 
• 145574-43-2 benzyl (1S,5S)-6-(tert-butyldimethylsilanyl)-4,7-dioxo-2,6-diazabicyclo<3.2.0>heptane-2-carboxylate 
• 214837-35-1 benzyl (1S,4S,5S)-4-(1-methyl-1H-tetrazol-5-ylsulfanyl)-7-oxo-2,6-diazabicyclo<3.2.0>heptanecarboxylate 
• 214837-37-3 benzyl (E)-(1S,5R)-4-(carbamoylmethylene)-7-oxo-2,6-diazabicyclo<3.2.0>heptane-2-carboxylate 
• 145574-42-1 benzyl (1S,4S,5S)-6-(tert-butyldimethylsilanyl)-4-hydroxy-7-oxo-2,6-diazabicyclo<3.2.0>heptane-2-carboxylate 

Relevant academic research and scientific papers

Structure-based design of β-lactamase inhibitors. 1. Synthesis and evaluation of bridged monobactams

Bridged monobactams are novel, potent, mechanism-based inhibitors of class C β-lactamases, designed using X-ray crystal structures of the enzymes. They stabilize the acyl-enzyme intermediate by blocking access of water to the enzyme-inhibitor ester bond.