214854-34-9

Upstream product

• 56929-45-4 4-((2-(1H-tetrazol-5-yl)hydrazono)methyl)-2-methoxyphenol 
• 1527-84-0 4-(hydrazonomethyl)-2-methoxyphenol 
• 584-13-4 4-amino-1,2,4-triazole 
• 121-33-5 vanillin 

Downstream Products

• 1025447-96-4 C₁₂H₁₂N₄O₃S 
• 1216963-54-0 C₁₈H₁₃Cl₂N₅O₃S 
• 1216963-13-1 C₁₈H₁₅N₅O₃S 
• 1216963-34-6 C₁₈H₁₄ClN₅O₃S 

Relevant academic research and scientific papers

Syntheses, in vitro α-amylase and α-glucosidase dual inhibitory activities of 4-amino-1,2,4-triazole derivatives their molecular docking and kinetic studies

Thirty-three 4-amino-1,2,4-triazole derivatives 1–33 were synthesized by reacting 4-amino-1,2,4-triazole with a variety of benzaldehydes. The synthetic molecules were characterized via 1H NMR and EI-MS spectroscopic techniques and evaluated for

Synthesis of nitrogenated lignin-derived compounds and reactivity with laccases. Study of their application in mild chemoenzymatic oxidative processes

The chemical synthesis of a series of lignin-derived nitrogenated compounds was performed in high yields (73-99%) through simple conventional chemical transformations starting from natural monomers such as vanillin, syringaldehyde or 3,4-dihydroxybenzaldehyde. The study of the vanillin-derived compounds as substrates for commercially available laccases from Trametes versicolor and Myceliophthora thermophila in oxidative transformations, generally led to the isolation of several dimeric species in high to excellent conversions (>70%), while for hydrazone derivatives a more rapidly oxidative coupling was evidenced by the formation of oligomers and/or polymers. Remarkably, vanillin was obtained due to the hydrolysis of some of the nitrogenated functional groups, such as the hydrazone or the hydrazono tetrazole. The three families of lignin-derived compounds can provide a great source of new laccase-mediator systems (LMS), the possibility of employing them for lignin modification being particularly attractive. Preliminary experiments showed promising levels of activity towards the oxidation of a monomer (veratryl alcohol, up to 70% conversion) and a dimer (adlerol, up to 22% conversion) lignin models, higher than those achieved with the natural vanillin and syringaldehyde (up to 7% conversion with veratryl alcohol and almost negligible conversion with adlerol), these processes being also highly influenced by the pH of the reaction medium.

Substituent swap affects the crystal structure and properties of: N -benzyl-4-amino-1,2,4-triazole related organic salts

An investigation into the effect of switching methoxy and hydroxyl groups on molecular salts is presented in this study. The salts HL1+·NO3- (1), L1·HL1+·ClO4- (2), L1·HL1+·H2PO4-·H2O (3), HL2+·NO3- (4), HL2+·ClO4- (5) and HL2+·H2PO4- (6) were synthesized and structurally characterized. The study was carried out by analyzing the crystal structure, properties and intermolecular interactions within each of the salts using IR and fluorescence spectra, TGA, Hirshfeld surface analyses and π?π stacking motifs. Salt 1 has a layered structure, while 4 has a distorted 3-D structure. Salt 2 possesses an edge-to-face type plane interaction, while 5 is formed with a twisted structure. It is important to note that water molecules play a key role in the 1-D chain structure of salt 3. The π?π stacking motif of salts 1-3 have a herringbone structure, while salts 3-6 exhibit a γ-structure. In addition, the competitive crystallization of the synthetic salts was investigated and found to be consistent with the measured solubility.

Synthesis and biological activity of 3-[4H-(1,2,4)-Triazolyl]-2,6-diaryl-1, 3,5-oxadiazine-4-thione

4-Amino-1,2,4-triazole (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding 4-(arylidene-amino)-4H-[1,2,4]-triazole (2a-h) in good yield. Rearrangement of compounds (2a-h) with benzoyl isothiocyanate/4-chloro-benzoyl isoth

Synthesis and biological activity of 3-[4H-(1,2,4)-triazolyl]-2-aryl-1,3- thiazolidin-4-ones

4-Amino-1,2,4-triazole (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding 4-(arylidene-amino)-4H-[1,2,4]-triazole (2 a-h) in good yields. Cyclocondensation of compounds (2 a-h) with thioglycolic acid yields 3-[4H-(1,2,4)