21487-28-5Relevant academic research and scientific papers
Anticonvulsant activity and succinate dehydrogenase inhibitory property of new substituted thiobarbiturates
Dhasmana,Barthwal,Pandey,et al.
, p. 635 - 637 (1981)
Eight 1-aryl-3-(2-pyridyl)thiobarbiturates were synthesized and evaluated for their anticonvulsant property and their ability to inhibit succinate dehydrogenase activity of rat brain homogenates. These substituted thiobarbiturates (100 mg./kg., i.p.) provided 20-60% protection against pentylenetetrazol-induced convulsions in albino mice. Low toxicity of these compounds was reflected by their high approximate LD50 values which were found to range from 500-1000 mg/kg. All substituted thiobarbiturates (1mM) inhibited in vitro succinate dehydrogenase activity and the degree of inhibition ranged from 10-72%.
Structural and spectral studies of N-2-(pyridyl)-, N-2-(4-, 5-, and 6-picolyl)- and N-2-(4,6-lutidyl)-N′-2-methoxyphenylthioureas
West, Douglas X.,Swearingen, John K.,Hermetet, Ann K.,Ackerman, Lily J.
, p. 95 - 105 (2007/10/03)
N-2-(pyridyl)-N′-2-methoxyphenylthiourea, PyTu2OMe, monoclinic, C2/c, a = 15.727(3), b = 11.251(2), c = 15.026(4) ?, β = 104.78(2)°, V = 2570.9(2) ?3 and Z = 8; N-2-(4-picolyl)-N′-2-methoxyphenylthiourea, 4PicTu2OMe, orthorhombic, Pbca, a = 11.
