214902-82-6

Basic information

• Product Name: Decladinose Roxithromycin (Roxithromycin Impurity B)
• Synonyms: Decladinose Roxithromycin (Roxithromycin Impurity B);(9E)-3-O-De(2,6-dideoxy-3-C-Methyl-3-O-Methyl-α-L-ribo-hexopyranosyl)erythroMycin 9-[O-[(2-Methoxyethoxy)Methyl]oxiMe];(9E)-3-O-de(2,6-dideoxy-3-C-Methyl-3-O-Methyl-α-L-ribo-hexopyranosyl)erythroMycin9-[O-[(2-Methoxyethoxy)Methyl]oxiMe];DecladinoseroxithroMycin;RoxithroMycin IMpurity B;(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-4,7,12,13-tetrahydroxy-10-(2-methoxyethoxymethoxyimino)-3,5,7,9,11,13-hexamethyl-oxa
• CAS NO: 214902-82-6
• Molecular Formula: C₃₃H₆₂N₂O₁₂
• Molecular Weight: 678.85158
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Chiral Reagents, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 214902-82-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 88-91°C
• Boiling Point: 773.9±70.0 °C(Predicted)
• Appearance: /
• Density: 1.24±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: DMSO (Slightly), Methanol (Sparingly), Water (Slightly)
• PKA: 13.02±0.70(Predicted)
• CAS DataBase Reference: Decladinose Roxithromycin (Roxithromycin Impurity B)(CAS DataBase Reference)
• NIST Chemistry Reference: Decladinose Roxithromycin (Roxithromycin Impurity B)(214902-82-6)
• EPA Substance Registry System: Decladinose Roxithromycin (Roxithromycin Impurity B)(214902-82-6)

Safety Data

• Hazardous Substances Data: 214902-82-6(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 214902-82-6 differently. You can refer to the following data:
1. Roxithromycin impurity B. The inactive metabolite (M1) of Roxithromycin.
2. Roxithromycin

Upstream product

• 80214-83-1 roxithromycin 

Downstream Products

• 214695-04-2 C₃₅H₆₂N₂O₁₃ 
• 214902-67-7 5-(3,4,6-trideoxy-2-O-acetyl-3-dimethylamino-β-D-xylo-hexopyranosyloxy)-3,6,11,12-tetrahydroxy-9-(2-methoxyethoxy)methoxyimino-2,4,6,8,10,12-hexamethylpentadecan-13-olide 

Relevant articles and documents

MODULATION OF IMMUNE RESPONSES BY ADMINISTRATION OF ROXITHROMYCIN OR ITS DERIVATIVE

Provided are compounds of formula (III) useful for modulation of immune responses, compositions comprising the compounds, and methods of use of such compositions for treating diseases or disorders involving an immune response. In certain embodiments, the compounds are useful for the treatment of diseases or disorders associated with transendothelial migration of T cells and activated T cells, and proinflammatory cytokine production from T cells and macrophages. Diseases or disorders that can be treated include arthritic and rheumatic disorders, such as rheumatoid arthritis.