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Decladinose Roxithromycin (Roxithromycin Impurity B) is an inactive metabolite (M1) of Roxithromycin, which is an antibiotic belonging to the macrolide class. It is characterized by its off-white solid appearance and is derived from the metabolism of Roxithromycin.

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  • 214902-82-6 Structure
  • Basic information

    1. Product Name: Decladinose Roxithromycin (Roxithromycin Impurity B)
    2. Synonyms: Decladinose Roxithromycin (Roxithromycin Impurity B);(9E)-3-O-De(2,6-dideoxy-3-C-Methyl-3-O-Methyl-α-L-ribo-hexopyranosyl)erythroMycin 9-[O-[(2-Methoxyethoxy)Methyl]oxiMe];(9E)-3-O-de(2,6-dideoxy-3-C-Methyl-3-O-Methyl-α-L-ribo-hexopyranosyl)erythroMycin9-[O-[(2-Methoxyethoxy)Methyl]oxiMe];DecladinoseroxithroMycin;RoxithroMycin IMpurity B;(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-4,7,12,13-tetrahydroxy-10-(2-methoxyethoxymethoxyimino)-3,5,7,9,11,13-hexamethyl-oxa
    3. CAS NO:214902-82-6
    4. Molecular Formula: C33H62N2O12
    5. Molecular Weight: 678.85158
    6. EINECS: N/A
    7. Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Chiral Reagents, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
    8. Mol File: 214902-82-6.mol
  • Chemical Properties

    1. Melting Point: 88-91°C
    2. Boiling Point: 773.9±70.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.24±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: -20°C Freezer, Under Inert Atmosphere
    8. Solubility: DMSO (Slightly), Methanol (Sparingly), Water (Slightly)
    9. PKA: 13.02±0.70(Predicted)
    10. CAS DataBase Reference: Decladinose Roxithromycin (Roxithromycin Impurity B)(CAS DataBase Reference)
    11. NIST Chemistry Reference: Decladinose Roxithromycin (Roxithromycin Impurity B)(214902-82-6)
    12. EPA Substance Registry System: Decladinose Roxithromycin (Roxithromycin Impurity B)(214902-82-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 214902-82-6(Hazardous Substances Data)

214902-82-6 Usage

Uses

Used in Pharmaceutical Industry:
Decladinose Roxithromycin (Roxithromycin Impurity B) is used as an impurity reference substance for the development and validation of analytical methods in the pharmaceutical industry. It helps in the identification, quantification, and quality control of Roxithromycin in drug formulations, ensuring the safety and efficacy of the final product.
Used in Research and Development:
In the field of research and development, Decladinose Roxithromycin (Roxithromycin Impurity B) serves as a valuable compound for studying the metabolic pathways of Roxithromycin and understanding its pharmacokinetics and pharmacodynamics. This knowledge can be applied to improve the drug's efficacy, safety, and overall performance in treating bacterial infections.
Used in Quality Control and Regulatory Compliance:
Decladinose Roxithromycin (Roxithromycin Impurity B) is utilized as a reference material in the quality control processes of pharmaceutical manufacturers. It aids in meeting regulatory requirements by providing a benchmark for the assessment of impurities in Roxithromycin drug products, thus ensuring compliance with industry standards and guidelines.

Check Digit Verification of cas no

The CAS Registry Mumber 214902-82-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,4,9,0 and 2 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 214902-82:
(8*2)+(7*1)+(6*4)+(5*9)+(4*0)+(3*2)+(2*8)+(1*2)=116
116 % 10 = 6
So 214902-82-6 is a valid CAS Registry Number.

214902-82-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-4,7,12,13-tetrahydroxy-10-(2-methoxyethoxymethoxyimino)-3,5,7,9,11,13-hexamethyl-oxacyclotetradecan-2-one

1.2 Other means of identification

Product number -
Other names (9E)-3-O-De(2,6-dideoxy-3-C-methyl-3-O-methyl-|A-L-ribo-hexopyranosyl)erythromycin 9-[O-[(2-Methoxyethoxy)methyl]oxime]

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:214902-82-6 SDS

214902-82-6Upstream product

214902-82-6Relevant articles and documents

MODULATION OF IMMUNE RESPONSES BY ADMINISTRATION OF ROXITHROMYCIN OR ITS DERIVATIVE

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Page/Page column 64-65, (2009/04/25)

Provided are compounds of formula (III) useful for modulation of immune responses, compositions comprising the compounds, and methods of use of such compositions for treating diseases or disorders involving an immune response. In certain embodiments, the compounds are useful for the treatment of diseases or disorders associated with transendothelial migration of T cells and activated T cells, and proinflammatory cytokine production from T cells and macrophages. Diseases or disorders that can be treated include arthritic and rheumatic disorders, such as rheumatoid arthritis.

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