214902-82-6

Basic information

• Product Name: Decladinose Roxithromycin (Roxithromycin Impurity B)
• Synonyms: Decladinose Roxithromycin (Roxithromycin Impurity B);(9E)-3-O-De(2,6-dideoxy-3-C-Methyl-3-O-Methyl-α-L-ribo-hexopyranosyl)erythroMycin 9-[O-[(2-Methoxyethoxy)Methyl]oxiMe];(9E)-3-O-de(2,6-dideoxy-3-C-Methyl-3-O-Methyl-α-L-ribo-hexopyranosyl)erythroMycin9-[O-[(2-Methoxyethoxy)Methyl]oxiMe];DecladinoseroxithroMycin;RoxithroMycin IMpurity B;(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-4,7,12,13-tetrahydroxy-10-(2-methoxyethoxymethoxyimino)-3,5,7,9,11,13-hexamethyl-oxa
• CAS NO: 214902-82-6
• Molecular Formula: C₃₃H₆₂N₂O₁₂
• Molecular Weight: 678.85158
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Chiral Reagents, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 214902-82-6.mol

Chemical Properties

• Melting Point: 88-91°C
• Boiling Point: 773.9±70.0 °C(Predicted)
• Appearance: /
• Density: 1.24±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: DMSO (Slightly), Methanol (Sparingly), Water (Slightly)
• PKA: 13.02±0.70(Predicted)
• CAS DataBase Reference: Decladinose Roxithromycin (Roxithromycin Impurity B)(CAS DataBase Reference)
• NIST Chemistry Reference: Decladinose Roxithromycin (Roxithromycin Impurity B)(214902-82-6)
• EPA Substance Registry System: Decladinose Roxithromycin (Roxithromycin Impurity B)(214902-82-6)

Safety Data

• Hazardous Substances Data: 214902-82-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Decladinose Roxithromycin (Roxithromycin Impurity B) is used as an impurity reference substance for the development and validation of analytical methods in the pharmaceutical industry. It helps in the identification, quantification, and quality control of Roxithromycin in drug formulations, ensuring the safety and efficacy of the final product.
Used in Research and Development:
In the field of research and development, Decladinose Roxithromycin (Roxithromycin Impurity B) serves as a valuable compound for studying the metabolic pathways of Roxithromycin and understanding its pharmacokinetics and pharmacodynamics. This knowledge can be applied to improve the drug's efficacy, safety, and overall performance in treating bacterial infections.
Used in Quality Control and Regulatory Compliance:
Decladinose Roxithromycin (Roxithromycin Impurity B) is utilized as a reference material in the quality control processes of pharmaceutical manufacturers. It aids in meeting regulatory requirements by providing a benchmark for the assessment of impurities in Roxithromycin drug products, thus ensuring compliance with industry standards and guidelines.

Upstream product

• 80214-83-1 roxithromycin 

Downstream Products

• 214695-04-2 C₃₅H₆₂N₂O₁₃ 
• 214902-67-7 5-(3,4,6-trideoxy-2-O-acetyl-3-dimethylamino-β-D-xylo-hexopyranosyloxy)-3,6,11,12-tetrahydroxy-9-(2-methoxyethoxy)methoxyimino-2,4,6,8,10,12-hexamethylpentadecan-13-olide 

Relevant articles and documents

MODULATION OF IMMUNE RESPONSES BY ADMINISTRATION OF ROXITHROMYCIN OR ITS DERIVATIVE

Provided are compounds of formula (III) useful for modulation of immune responses, compositions comprising the compounds, and methods of use of such compositions for treating diseases or disorders involving an immune response. In certain embodiments, the compounds are useful for the treatment of diseases or disorders associated with transendothelial migration of T cells and activated T cells, and proinflammatory cytokine production from T cells and macrophages. Diseases or disorders that can be treated include arthritic and rheumatic disorders, such as rheumatoid arthritis.