214903-43-2Relevant academic research and scientific papers
Synthesis and biological evaluation of quinoxaline derivatives as tubulin polymerization inhibitors that elevate intracellular ROS and triggers apoptosis via mitochondrial pathway
Qi, Jianguo,Huang, Jing,Zhou, Xiaomin,Luo, Wen,Xie, Jiaxin,Niu, Linqiang,Yan, Zhijie,Luo, Yang,Men, Yuhui,Chen, Yanan,Zhang, Yahong,Wang, Jianhong
, p. 617 - 627 (2019/01/18)
A series of novel quinoxaline derivatives were synthesized and evaluated for their antiproliferative activity in three human cancer cell lines. Compound 12 exhibited the most potent antiproliferative activity with IC50 in the range of 0.19–0.51
Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARγ partial agonist
Sime, Mairi,Allan, Amanda C.,Chapman, Paul,Fieldhouse, Charlotte,Giblin, Gerard M.P.,Healy, Mark P.,Lambert, Millard H.,Leesnitzer, Lisa M.,Lewis, Ann,Merrihew, Raymond V.,Rutter, Richard A.,Sasse, Rosemary,Shearer, Barry G.,Wilson, Timothy M.,Xu, Robert X.,Virley, David J.
scheme or table, p. 5568 - 5572 (2011/10/09)
The peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated nuclear receptor, thought to play a role in energy metabolism, glucose homeostasis and microglia-mediated neuroinflammation. A novel benzimidazole series of centrally penetrant PPARγ partial agonists has been identified. The optimization of PPARγ activity and in vivo pharmacokinetics leading to the identification of GSK1997132B a potent, metabolically stable and centrally penetrant PPARγ partial agonist, is described.
Synthesis of some new benzimidazolecarboxamides and evaluation of their antimicrobial activity
Goeker, Hakan,Tuncbilek, Meral,Ayhan, Guelguen,Altanlar, Nurten
, p. 415 - 420 (2007/10/03)
A series of 1,2-disubstituted benzimidazole-5(6)-carboxamides was prepared and evaluated in vitro for antimicrobial activity against Staphyloccus aureus, Escherichia coli and Candida albicans. The precursor benzimidazolecarboxylic acids 4a-c and 9a-c were
