214907-25-2

Upstream product

• 768-60-5 4-methoxyphenylacetylen 
• 149777-83-3 2-[2-(4-methoxyphenyl)vinyl]-4,4,5,5-tetramethyl[1,3,2]dioxaborolane 
• 274-07-7 benzo[1,3,2]dioxaborole 

Downstream Products

• 1158805-49-2 C₁₉H₂₄O₅ 
• 1158805-58-3 C₁₉H₂₄O₅ 
• 1170193-19-7 methyl (E)-2-(5-(4-(4-methoxystyryl)phenyl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butyrate 
• 43212-67-5 1-(4-methoxyphenyl)-4-(4-methoxyphenyl)-1,3-butadiene 
• 1155956-96-9 (S,E)-1-(4-fluorophenyl)-3-(hydroxymethyl)-5-(4-methoxyphenyl)pent-4-en-1-one 
• 1155957-02-0 (S,E)-1-(4-chlorophenyl)-3-(hydroxymethyl)-5-(4-methoxyphenyl)pent-4-en-1-one 
• 1155957-06-4 (S,E)-3-(hydroxymethyl)-5-(4-methoxyphenyl)-1-(naphthalen-2-yl)pent-4-en-1-one 
• 1155956-93-6 (S,E)-3-(hydroxymethyl)-5-(4-methoxyphenyl)-1-phenylpent-4-en-1-one 
• 159974-67-1 (S)-3,4-dihydroxy-1-phenylbutan-1-one 
• 1155956-98-1 (S,E)-1-(4-bromophenyl)-3-(hydroxymethyl)-5-(4-methoxyphenyl)pent-4-en-1-one 
• 1223435-08-2 (E)-2-(4-methoxystyryl)-1-methyl-1H-imidazole-4,5-dicarbonitrile 
• 85502-87-0 (E)-4'-chloro-4-methoxychalcone 
• 22252-15-9 trans-4-methoxychalcone 
• 1612777-55-5 (S,E)-2-(4-(4-methoxyphenyl)but-3-en-2-yl)naphthalene 

Relevant academic research and scientific papers

Synthesis of Acrylonitriles via Mild Base Promoted Tandem Nucleophilic Substitution-Isomerization of α-Cyanohydrin Methanesulfonates

Main observation and conclusion: We have developed an efficient synthesis of acrylonitriles via mild base promoted tandem nucleophilic substitution-isomerization of α-cyanohydrin methanesulfonates with alkenylboronic acids. This transition metal-free protocol works under simple and mild conditions and offers good chemical yields for a wide range of substrates and demonstrates good functional group tolerance. (Figure presented.).

Synthesis of α-Borylated Ketones by Regioselective Wacker Oxidation of Alkenylboronates

As part of a program aimed at metal-catalyzed oxidative transformations of molecules with carbon-metalloid bonds, the synthesis of α-borylated ketones is reported via regioselective TBHP-mediated Wacker-type oxidation of N-methyliminodiacetic acid (MIDA)-protected alkenylboronates. The observed regioselectivity correlates with the hemilabile nature of the B-N dative bond in the MIDA boronate functional group, which allows boron to guide selectivity through a neighboring group effect.

Oxalyl Boronates Enable Modular Synthesis of Bioactive Imidazoles

Described herein is the preparation of oxalyl boronate building blocks and their application for the construction of heterocycles. The oxalyl unit, readily accessible through commercially available starting materials, enables a modular approach for the synthesis of imidazoles. A variety of aromatic, heteroaromatic, and alkyl carboxaldehydes were condensed with oxalyl boronates to afford substituted boryl imidazoles in a regiocontrolled fashion. Subsequent palladium-catalyzed cross-coupling with haloarenes furnished the desired trisubstituted imidazole scaffolds. To demonstrate the utility of these scaffolds, potent inhibitors of the serine/threonine-protein kinase STK10 were synthesized.