85502-87-0

Basic information

• Product Name: (2E)-1-(4-chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
• Synonyms: (2E)-1-(4-Chlorophenyl)-3-(4-methoxyphenyl)-2-propen-1-one; (2E)-1-(4-Chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one; 2-Propen-1-one, 1-(4-chlorophenyl)-3-(4-methoxyphenyl)-, (2E)-; 6552-63-2; trans-4'-Chloro-4-methoxychalcone
• CAS NO: 85502-87-0
• Molecular Formula: C₁₆H₁₃ClO₂
• Molecular Weight: 272.7262
• Mol File: 85502-87-0.mol
• Article Data: 37

Chemical Properties

• Boiling Point: 434.8°C at 760 mmHg
• Flash Point: 176.1°C
• Density: 1.207g/cm³
• Vapor Pressure: 9.21E-08mmHg at 25°C
• Refractive Index: 1.613
• CAS DataBase Reference: (2E)-1-(4-chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-1-(4-chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one(85502-87-0)
• EPA Substance Registry System: (2E)-1-(4-chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one(85502-87-0)

Safety Data

• Hazardous Substances Data: 85502-87-0(Hazardous Substances Data)

Usage

Description

(2E)-1-(4-chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one is an organic compound characterized by its molecular formula C16H13ClO2. It is a ketone with a chlorophenyl group and a methoxyphenyl group attached to a prop-2-en-1-one chain. (2E)-1-(4-chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one exhibits diverse biological activities and has potential applications in the pharmaceutical and agrochemical industries. However, it is important to handle it with caution due to its potential toxic or irritant effects. Further research is necessary to fully understand its potential uses and risks.

Uses

Used in Pharmaceutical Industry:
(2E)-1-(4-chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one is used as a pharmaceutical intermediate for the development of drugs with diverse biological activities. Its unique structure allows for the creation of new compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, (2E)-1-(4-chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one is used as a precursor for the synthesis of agrochemicals with potential pesticidal or herbicidal properties. Its chemical structure can be modified to create new compounds with improved efficacy and selectivity in controlling pests and weeds.

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Downstream Products

• 1651829-83-2 1-(4-(4-chlorobenzoyl)-5-(4-methoxyphenyl)-2-methylfuran-3-yl)ethanone 
• 1228151-41-4 6-(4-chlorophenyl)-4-(4-methoxyphenyl)-3,4-dihydropyrimidin-2(1H)-one 
• 1619265-89-2 C₂₄H₂₃ClN₂O 
• 1620197-88-7 N'-(1-(4-chlorophenyl)-3-(4-methoxyphenyl)allylidene)-4-methyl-1,2,3-thiadiazole-5-carbohydrazide 
• 1620197-89-8 N'-(1-(4-chlorophenyl)-3-(4-methoxyphenyl)allylidene)-4-methoxybenzohydrazide 
• 1449012-93-4 3-bromo-1-(4-chlorophenyl)-3-(4-methoxyphenyl)propane-1,2-dione 
• 1449465-04-6 5-(4-chlorophenyl)-4-methoxy-7-(4-methoxyphenyl)-2-methylsulfanyl-7H-thiopyrano[2,3-d]pyrimidine 
• 1449464-84-9 (E)-1-[4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidin-5-yl]-1-(4-chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-ol 
• 1422433-41-7 C₂₀H₁₇ClN₂O₂ 
• 1394072-16-2 1-(3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)pyrazol-1-yl)-2-(5-(4-methoxy phenyl)-1H-tetrazol-1-yl)ethanone 

Relevant articles and documents

Synthesis, characterization, crystal structure, TGA and blue fluorescence of 6-(4-chlorophenyl)-4-(4-methoxyphenyl)-2-methoxynicotinonitrile

6-(4-Chlorophenyl)-4-(4-methoxyphenyl)-2-methoxynicotinonitrile (1) was synthesized by cyclization reaction of a chalcone derivative and malononitrile and characterized by FT-IR, UV-Vis, 1H NMR and single crystal X-ray diffraction. The crystal

From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity

A ligand-based approach involving systematic modifications of a trisubstituted pyrazoline scaffold derived from the COX2 inhibitor, celecoxib, was used to develop novel PDE5 inhibitors. Novel pyrazolines were identified with potent PDE5 inhibitory activit

Novel potent and selective DPP-4 inhibitors: Design, synthesis and molecular docking study of dihydropyrimidine phthalimide hybrids

Background: Dipeptidyl peptidase-4 (DPP-4) inhibitors have emerged as antihyperglycemic agents that improve glycemic control in type 2 diabetic patients, either as monotherapy or in combination with other antidiabetic drugs. Methods: A novel series of dihydropyrimidine phthalimide hybrids was synthesized and evaluated for their in vitro and in vivo DPP-4 inhibition activity and selectivity using alogliptin as reference. Oral glucose tolerance test was assessed in type 2 diabetic rats after chronic treatment with the synthesized hybrids ± metformin. Cytotoxicity and antioxidant assays were performed. Additionally, molecular docking study with DPP-4 and structure activity relationship of the novel hybrids were also studied. Results: Among the synthesized hybrids, 10g, 10i, 10e, 10d and 10b had stronger in vitro DPP-4 inhibitory activity than alogliptin. Moreover, an in vivo DPP-4 inhibition assay revealed that 10g and 10i have the strongest and the most extended blood DPP-4 inhibitory activity compared to alogliptin. In type 2 diabetic rats, hybrids 10g, 10i and 10e exhibited better glycemic control than alogliptin, an effect that further supported by metformin combination. Finally, 10j, 10e, 10h and 10d had the highest radical scavenging activity in DPPH assay. Conclusions: Hybrids 10g, 10i and 10e are potent DPP-4 inhibitors which may be beneficial for T2DM treatment.