214908-35-7

Basic information

• Product Name: 1-(3,3-Dimethyl-piperidin-1-yl)-5-phenyl-pentan-1-one
• Synonyms: 1-(3,3-Dimethyl-piperidin-1-yl)-5-phenyl-pentan-1-one
• CAS NO: 214908-35-7
• Molecular Weight: 273.418
• Mol File: 214908-35-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3,3-Dimethyl-piperidin-1-yl)-5-phenyl-pentan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,3-Dimethyl-piperidin-1-yl)-5-phenyl-pentan-1-one(214908-35-7)
• EPA Substance Registry System: 1-(3,3-Dimethyl-piperidin-1-yl)-5-phenyl-pentan-1-one(214908-35-7)

Safety Data

• Hazardous Substances Data: 214908-35-7(Hazardous Substances Data)

Upstream product

• 1193-12-0 3,3-dimethylpiperidine 
• 20371-41-9 5-phenylvaleric acid chloride 
• 2270-20-4 5-Phenylpentanoic acid 

Relevant articles and documents

N-[ω-(tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine are highly potent and selective σ1 or σ2 ligands

Several 3,3-dimethyl-N-[ω-(tetrahydronaphthalen-1-yl)alkyl]piperidine derivatives and some related compounds were prepared. Their affinities and σ-subtype selectivities were investigated by radioligand binding assays, labeling σ1 receptors with [3H]-SKF 10047 and σ2 receptors with [3H]- DTG. Many tested compounds bound σ1 and/or σ2 receptors with nanomolar or subnanomolar IC50 values. Compound (+)-22, (+)-3,3-dimethyl-1-[3-(5- methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-n-propyl]piperidine, was the most potent (IC50 = 0.089 nM) and selective σ1 ligand (1340-fold), showing a 10-fold enantioselectivity. Compounds 29 (3,3-dimethyl-1-[4 (6-methoxy- 1,2,3,4-tetrahydronaphthalen-1-yl)-n-butyl]piperidine) and 31 (3,3-dimethyl- 1-[5-(1,2,3,4-tetrahydronaphthalen-1-yl)-n-pentyl]piperidine) were highly potent (IC50 = 0.016 nM and IC50 = 0.008 nM, respectively) and highly selective σ2 ligands (more than 100 000-fold).