21493-88-9

Upstream product

• 534-22-5 2-methylfuran 
• 59046-28-5 p-toluoyl-1H-1,2,3-benzotriazole 
• 874-60-2 4-methyl-benzoyl chloride 
• 14003-11-3 5-methylfuran-2-carbonyl chloride 
• 108-88-3 toluene 
• 1192137-70-4 5-[hydroxy-(4-methylphenyl)methyl]-2-(N-tosylaminomethyl)furan 

Relevant academic research and scientific papers

Synthesis and some transformations of 5-(N-tosylaminomethyl)furfuryl alcohols

Preparative methods were developed for the synthesis of 5-(N-tosylaminomethyl)furfuryl alcohols, and their behavior during the action of acidic catalysts was studied. It was established that the furan ring of these compounds is stable in the presence of o

C-acylation of 2-methylfuran and thiophene using N-acylbenzotriazoles

Reactions of 2-methylfuran and thiophene with readily available N-acylbenzotriazoles (RCOBt, where R = 4-tolyl, 4-methoxyphenyl, benzyl, 4-nitrophenyl, 4-diethylaminophenyl, 2-pyridyl and 1-naphthyl) in the presence of TiCl4 or ZnBr2 produced 2-methyl-4-acylfurans 2a-e and 2-acylthiophenes 3a-f in average yields of 54 % and 75 %, respectively. Literature yields for the preparation of the same compounds are significantly lower.

1-(substituted benzyl)-3-(substituted aryl)-condensed pyrazole derivatives and processes of making the same

The invention pertains to a process for preparing (1-substituted benzyl)-3-(hydroxy-carbonyl aryl) condensed pyrazoles or (1-substituted benzyl)-3-(hydroxymethyl aryl) condensed pyrazoles comprising the steps of: (a) reacting compound I and compound II, or compound III and compound IV, to produce compound V, which is a substituted aryl ketone, as follows: STR1 wherein Ar2 and At3 can be, independently, STR2 R1 is H, C1-3 alkyl, or X (halogen), R3 is H, C1-3 alkyl, X (halogen), or --OR radical, and R is H or C1-3 alkyl; the process comprising the following steps of: R2 represents CH2 OR, H, COOR, C1-3 alkyl, or X (halogen); (b) reacting the compound V with a hydrazine compound to form a hydrazone compound; (c) reacting the hydrazone compound compound with trifluoride etherate (BF3 ·Et2 O) to form a 1-(substituted benzyl) 3-(substituted aryl) condensed pyraxzole, which is represented by the following formula of STR3 Compound X can be further hydrolyzed or reduced to form corresponding carboxylic acids or alcohols.

1-Benzyl-3-(substituted aryl)-condensed pyrazole derivatives as inhibitors of platelet aggregation

1-Benzyl-3-(substituted aryl) condensed pyrazoles of the general formula (A): wherein, R1 represents H, C1 3 alkyl, halogen, or -OR, in which R represents H or C1 3 alkyl; represents wherein R2/