214958-29-9Relevant academic research and scientific papers
One-pot NBS-promoted synthesis of imidazoles and thiazoles from ethylarenes in water
Chen, Liang,Zhu, Huajian,Wang, Jiang,Liu, Hong
, (2019)
A facile and eco-friendly method has been developed for the synthesis of imidazoles and thiazoles from ethylarenes in water. The reaction proceeds via in situ formation of α-bromoketone using NBS as a bromine source as well as an oxidant, followed by trapping with suitable nucleophiles to provide the corresponding products in good yields under metal-free conditions.
