214958-32-4

Basic information

• Product Name: ethyl 6-iodoH-imidazo[1,2-a]pyridine-2-carboxylate
• Synonyms: ethyl 6-iodoH-imidazo[1,2-a]pyridine-2-carboxylate;ethyl 6-iodo-5H-imidazo[2,1-b][1,3]oxazine-2-carboxylate;6-Iodo-iMidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester;Ethyl 6-iodo-1H-imidazo[1,2-a]pyridine-2-carboxylate
• CAS NO: 214958-32-4
• Molecular Formula: C₁₀H₉IN₂O₂
• Molecular Weight: 316.09
• Product Categories: CHIRAL CHEMICALS
• Mol File: 214958-32-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 177-179°
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.83g/cm³
• Refractive Index: 1.68
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.75±0.50(Predicted)
• CAS DataBase Reference: ethyl 6-iodoH-imidazo[1,2-a]pyridine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 6-iodoH-imidazo[1,2-a]pyridine-2-carboxylate(214958-32-4)
• EPA Substance Registry System: ethyl 6-iodoH-imidazo[1,2-a]pyridine-2-carboxylate(214958-32-4)

Safety Data

• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 214958-32-4(Hazardous Substances Data)

Usage

General Description

Ethyl 6-iodoH-imidazo[1,2-a]pyridine-2-carboxylate is a complex organic compound that is a derivative of both imidazole and pyridine, two types of heterocyclic aromatic compounds that contain nitrogen. The presence of the iodine atom and ester functional group (carboxylate) gives this compound specific properties and reactivity patterns. As an iodinated heterocyclic compound, it may be used as a building block in various chemical syntheses, particularly in the development of pharmaceutically relevant substances. Its exact properties, including melting point, boiling point, and solubility, would depend on its specific structural configuration. However, as is typical of organic compounds, it is likely to be insoluble in water and soluble in organic solvents.

InChI:InChI=1/C10H9IN2O2/c1-2-15-10(14)8-6-13-5-7(11)3-4-9(13)12-8/h3-6H,2H2,1H3

Upstream product

• 20511-12-0 2-amino-5-iodopyridine 
• 74100-43-9 2-bromo-2-oxoacetic acid ethyl ester 
• 70-23-5 ethyl Bromopyruvate 

Downstream Products

• 1167623-24-6 SR₂₄₂₃₇ 
• 478040-59-4 6-iodo-1H-imidazo[1,2-a]pyridine-2-carboxylic acid 
• 1167625-78-6 N-(3,5-difluorophenyl)-6-iodoimidazo[1,2-a]pyridine-2-carboxamide 
• 214958-36-8 4-[(E)-2-(6-Iodo-imidazo[1,2-a]pyridin-2-yl)-vinyl]-benzonitrile 

Relevant articles and documents

Development of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson's disease

In the course of a programme aimed at identifying Nurr1/NOT agonists for potential treatment of Parkinson's disease, a few hits from high throughput screening were identified and characterized. A combined optimization pointed to a very narrow and stringen

Synthesis, molecular docking and anti-mycobacterial evaluation of new imidazo[1,2-a]pyridine-2-carboxamide derivatives

New anti-tubercular agents, imidazo[1,2-a]pyridine-2-carboxamide derivatives (5a-q) have been designed and synthesized. The structural considerations of the designed molecules were further supported by the docking study with a long-chain enoyl-acyl carrier protein reductase (InhA). The chemical structures of the new compounds were characterized by IR, 1H NMR, 13C NMR, HRMS and elemental analysis. In addition, single crystal X-ray diffraction has also been recorded for compound 5f. Compounds were evaluated in vitro against Mycobacterium tuberculosis H37Rv, and cytotoxicity against HEK-293T cell line. Amongst the tested compounds 5j, 5l and 5q were emerged as good anti-tubercular agents with low cytotoxicity. The structure-anti TB activity relationship of these derivatives was explained by molecular docking.

NOVEL COMPOUNDS AS PHARMACEUTICAL AGENTS

The current invention relates to compounds of the formula:(Ia) and the pharmaceutically acceptable salts thereof and their use as TGF-beta signal transduction inhibitors for treating cancer and other diseases in a patient in need thereof by administration of said compounds.