214960-41-5

Upstream product

• 108-22-5 Isopropenyl acetate 
• 80783-14-8 1-phenylmercapto-2,2-dimethyl-butan-3-one 
• 17510-44-0 (1,2-dimethyl-propenyloxy)-trimethyl-silane 
• 7205-91-6 phenylthiomethyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 325706-83-0 (S)-5-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(Z)-ylidene]-7-(4-methoxy-benzyloxy)-2,2-dimethyl-1-phenylsulfanyl-8-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-octan-3-ol 
• 325706-75-0 (7S,9R,10R)-5-[(E)-2-tert-butyldiphenylsilyloxyethylidene]-7-(4-methoxybenzyloxy)-2,2-dimethyl-1-phenylsulfanyl-9,10-di-O-isopropylideneundecan-3-one 
• 214960-55-1 (S)-5-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-7-(4-methoxy-benzyloxy)-9-(2-methoxy-ethoxymethoxy)-2,2-dimethyl-1-phenylsulfanyl-nonan-3-one 

Relevant academic research and scientific papers

Synthesis of the C(17)-C(27) fragment of the 20-deoxybryostatins

A synthesis of the C(17)-C(27) fragment of the 20-deoxybryostatins is described in which the key step is a palladium(0) catalysed coupling of a tributyltin enolate with a vinylic bromide. (C) 2000 Elsevier Science Ltd.

An approach to the C(17)-C(24) fragment of bryostatins: Applications of stereoselective trisubstituted alkene formation by palladium(0) catalysed coupling of enol acetates and vinylic bromides

The enol acetate 26 couples stereospecifically with the vinylic bromides 25 and 29 in the presence of tributyltin methoxide and a catalytic amount of dichlorobis(tri-o-tolylphosphine)palladium to give the βγ-unsaturated ketones 27 and 30 with retention of