214976-36-0 Usage
Uses
Used in Pharmaceutical Industry:
3-Chloro-5-Methoxyisonicotinic acid is used as a building block for the synthesis of various biologically active compounds and pharmaceutical intermediates. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 3-Chloro-5-Methoxyisonicotinic acid is utilized as a key intermediate for the preparation of a wide range of chemical compounds. Its reactivity and functional groups make it a valuable component in the synthesis of complex organic molecules.
Used in Antimicrobial Applications:
3-Chloro-5-Methoxyisonicotinic acid is studied for its potential antifungal and antibacterial properties, making it a candidate for use in antimicrobial agents. Its ability to inhibit the growth of certain microorganisms could contribute to the development of new treatments for infections.
Overall, 3-Chloro-5-Methoxyisonicotinic acid is a promising chemical with diverse applications in the fields of chemistry and medicine, offering opportunities for the development of new pharmaceuticals and synthetic compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 214976-36-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,4,9,7 and 6 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 214976-36:
(8*2)+(7*1)+(6*4)+(5*9)+(4*7)+(3*6)+(2*3)+(1*6)=150
150 % 10 = 0
So 214976-36-0 is a valid CAS Registry Number.
214976-36-0Relevant academic research and scientific papers
Synthesis of hydroxy-substituted aza-analogues of antitumor anthrapyrazoles
Paul Krapcho,Gallagher, Cynthia E.,Hammach, Abdelhakim,Hacker, Miles P.,Menta, Ernesto,Oliva, Ambrogio,Domenico, Roberto Di,Re, Giovanni Da,Lotto, Andrea,Spinelli, Silvano
, p. 895 - 906 (2007/10/03)
Synthetic routes have been developed which lead to ring-hydroxylated aza-analogues of antitumor anthrapyrazoles, namely, 2,5- bis[(aminoalkyl)amino] substituted 10-hydroxyindazo[3,4-fg]isoquinolin- 6(2H)-ones 1 and 7-hydroxyindazolo[4,3-gh]isoquinolin-6(2H)-ones 2. The regiospecific synthesis of 6,9-dihalo-4-hydroxybenz[g]isoquinolines 3 and 4 has been accomplished. Intermediate 3 was constructed in a multistep process involving Diels-Alder chemistry of benzolacrylates whereas 4 was assembled using Ni(II) mediated coupling of methyl 3-chloro-5-methoxyisonicotinate (15b) with the organic zinc reagent 18 derived from 2-fluoro-5-chlorobenzyl bromide (17). After protection of the hydroxy group with a p-methoxybenzyl moiety, the different nucleofugacities of the leaving groups present in 10 and 20 allowed sequential displacements by substituted hydrazines and amines, respectively, to lead to the desired p-methoxybenzyl protected analogues 12 and 22. Deprotection led to the side arm modified compounds 1 and 2. The displacements of 21a and 21b with N,N-dimethylethylenediamine also led to the tri[(aminoalkyl)amino]substituted analogues 23s and 23b, respectively, which arose from further S(N)Ar substitutions of the p-methoxybenzyloxy group.
