214977-38-5Relevant articles and documents
Hetarynic synthesis and chemical transformation of dihydrodipyridopyrazines
Blanchard, Stéphanie,Rodriguez, Ivan,Kuehm-Caubère, Catherine,Renard, Pierre,Pfeiffer, Bruno,Guillaumet, Gérald,Caubère, Paul
, p. 3513 - 3524 (2002)
Unprecedented dihydrodipyridopyrazines were easily obtained by hetarynic dimerization of 2-alkylamino-3-halogenopyridines in the presence of the complex base NaNH2-tBuONa. Derivatizations of the new heterocycles are described. The anticancer ac
Efficient synthesis of 3-bromo-2-[(N-substituted)amino]pyridines and their hetarynic cyclization
Grig-Alexa, Irina-Claudia,Finaru, Adriana-Luminita,Ivan, Lucia,Caubère, Paul,Guillaumet, Gérald
, p. 619 - 628 (2006)
A variety of 3-bromo-2-[(N-substituted)amino]pyridines were obtained via two convenient methods and were used in the hetarynic synthesis of the corresponding N-substituted dihydro-dipyridopyrazines. Georg Thieme Verlag Stuttgart.
Towards New Tricyclic Motifs: Intramolecular C–H Arylation as the Key Step in a Formal [3+3] Cyclocondensation Strategy
Vrijdag, Johannes L.,De Ruysscher, Dries,De Borggraeve, Wim M.
, p. 1465 - 1474 (2017/04/01)
Tricyclic scaffolds structurally related to the well-known benzodiazepine class of drugs show diverse biological activities strikingly different from those of their benzodiazepine counterparts. Interested by this scaffold-hopping perspective, we previousl
Reductive cyclization of halo-ketones to form 3-hydroxy-2-oxindoles via palladium catalyzed hydrogenation: a hydrogen-mediated Grignard addition
Shin, Inji,Ramgren, Stephen D.,Krische, Michael J.
supporting information, p. 5776 - 5780 (2015/08/03)
Abstract The reductive cyclization of N-oxoacyl ortho-bromoanilides to form 3-hydroxy-2-oxindoles under the conditions of palladium catalyzed hydrogenation is described. This work may be viewed as a prelude to intermolecular hydrogen-mediated Grignard-typ
Synthesis of nitro N,N′-dipyridinylamines via oxidative nucleophilic substitution of hydrogen
Patriciu, Oana-Irina,Pillard, Christelle,Finaru, Adriana-Luminita,Sandulescu, Ioan,Guillaumet, Gerald
, p. 3868 - 3876 (2008/09/17)
The amination of 3-nitropyridines with aromatic amides generated from various aminopyridine derivatives proceeded unexpectedly in the position para to the nitro group, giving the oxidative nucleophilic substitution of hydrogen (ONSH) derived compounds. After optimization, this reaction allowed easy access to interesting 3-nitro-substituted N,N′-dipyridinylamines. Georg Thieme Verlag Stuttgart.
5,10-dihydrodipyrido[2,3-b:2,3-e]pyrazin and 5,10-dihydrodipyrido[2,3-b:3,2-e]pyrazin compounds
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, (2008/06/13)
A compound selected from those of formula (I): wherein: X represents N, C or CH, Y represents N when X represents C or CH, or Y represents C or CH when X represents N, R1 represents an optionally substituted alkyl, R2 and R3, which may be identical or different, represent Z or W, as defined in the description, their isomers and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.