521984-94-1

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine, 1-methyl-2-phenyl-
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine,1-methyl-2-phenyl
• CAS NO: 521984-94-1
• Molecular Formula: C14H12N2
• Molecular Weight: 208.263
• Mol File: 521984-94-1.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine, 1-methyl-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine, 1-methyl-2-phenyl-(521984-94-1)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine, 1-methyl-2-phenyl-(521984-94-1)

Safety Data

• Hazardous Substances Data: 521984-94-1(Hazardous Substances Data)

Upstream product

• 591-50-4 iodobenzene 
• 27257-15-4 1-methyl-1H-pyrrolo[2,3-b]pyridine 
• 10586-52-4 2-phenyl-1H-pyrrolo[2,3-b]pyridine 
• 74-88-4 methyl iodide 
• 13534-99-1 2-Amino-3-bromopyridine 
• 536-74-3 phenylacetylene 
• 113975-23-8 methyl(3-iodopyridin-2-yl)amine 
• 214977-38-5 N-(3-bromopyridin-2-yl)-N-methylamine 
• 71-43-2 benzene 
• 98-80-6 phenylboronic acid 
• 271-63-6 7-Azaindole 
• 116026-94-9 2--3-pyridinecarboxaldehyde 
• 945607-94-3 C₁₃H₁₆Cl₂N₂O₂ 
• 1009104-87-3 C₁₃H₁₆Br₂N₂O₂ 

Downstream Products

• 945608-15-1 3-iodo-1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridine 
• 521984-95-2 1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 
• 87613-34-1 1-methyl-2-phenyl-1H-indole-3-carbonitrile 
• 1198277-91-6 N,N-dimethyl-1-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methanamine 
• 1009104-85-1 ((E)-1-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one) 

Relevant articles and documents

Synthesis of pyrrolo-heterocycles via Pd-loaded zeolite catalyzed annulation of o- haloaromatic amine with terminal alkynes

A Pd-loaded zeolite-catalyzed heteroannulation of various 2-iodopyridines and 2-iodoquinolines with terminal alkyne is demonstrated. This approach provides a rapid and convergent synthesis toward a diverse range of pyrrolo-pyridines (azaindoles) and pyrrolo-quinoline ring systems. The Pd-zeolite catalyst can be reused within the same reaction without reactivation of the Pd-zeolite catalyst. Furthermore, Pd-zeolite catalysis is an interesting alternative to homogeneous catalysis for the synthesis of heterocycles.

Direct C-H bond activation: Palladium-on-carbon as a reusable heterogeneous catalyst for C-2 arylation of indoles with arylboronic acids

Direct C(sp2)-H bond functionalization of indoles with arylboronic acids is achieved using palladium supported on carbon as a reusable heterogeneous catalyst in the presence of an oxidant under mild conditions. The current protocol formed exclusive C-2 selective products without the aid of any ligand or directing group. The catalyst is reusable for up to four catalytic cycles with the retention of catalytic efficiency.

Palladium-catalyzed regioselective C-2 arylation of 7-azaindoles, indoles, and pyrroles with arenes

A palladium-catalyzed regioselective C-2 arylation of 7-azaindoles, indoles, and pyrroles with arenes has been developed. This study unveils that a critical substrate dependent acid concentration is essential for achieving exclusive C-2 selectivity as wel