2150-95-0

Usage

Uses

Used in Pharmaceutical Research:
N-(3,4-dichlorophenyl)butanamide is used as a research chemical for investigating its potential therapeutic effects in treating various neurological and psychiatric disorders, including anxiety, depression, and schizophrenia.
Used in Organic Synthesis:
NPB is used as a reagent in organic synthesis, contributing to the development of new chemical compounds and reactions.
Used in Pharmaceutical Production:
N-(3,4-dichlorophenyl)butanamide serves as an intermediate in the production of pharmaceuticals, playing a crucial role in the synthesis of various medications.

Upstream product

• 106-31-0 butanoic acid anhydride 
• 95-76-1 m,p-dichloroaniline 
• 99-54-7 3,4-dichloronitrobenzene 
• 107-92-6 butyric acid 

Relevant academic research and scientific papers

Reductive acylation of nitroarenes to anilides by sodium sulfite in carboxylic acids

A facile and efficient reductive acylation of aromatic nitro compounds to corresponding anilides using a sodium sulfite-carboxylic acid system for the first time has been reported. The sodium sulfite reagent provides the colorless reductant in combination with stoichiometric amounts of carboxylic acid and enables the formation of anilides from nitroarenes without any additives in good to excellent yields with high purities and simple work-up. Furthermore, this protocol provides a novel and complementary access to some industrially important chemicals in kilogram scale under mild conditions.

A novel synthesis of N-arylamides from nitroarenes via reductive N-acylation with red phosphorus and iodine

A series of N-arylamides and imides were synthesized via reductive N-acylation of nitroarenes with red phosphorus and carboxylic acids, catalyzed by iodine or iodides; an I /I° redox cycle was proposed to promote the reaction. Georg Thieme Verlag Stuttgart.