215119-35-0Relevant academic research and scientific papers
Discovery and evaluation of selective N-type calcium channel blockers: 6-Unsubstituted-1,4-dihydropyridine-5-carboxylic acid derivatives
Yamamoto, Takashi,Niwa, Seiji,Tokumasu, Munetaka,Onishi, Tomoyuki,Ohno, Seiji,Hagihara, Masako,Koganei, Hajime,Fujita, Shin-Ichi,Takeda, Tomoko,Saitou, Yuki,Iwayama, Satoshi,Takahara, Akira,Iwata, Seinosuke,Shoji, Masataka
, p. 3639 - 3642 (2012/07/17)
A structure-activity relationship study of 6-unsubstituted-1,4- dihydropyridine and 2,6-unsubstituted-1,4-dihydropyridine derivatives was conducted in an attempt to discover N-type calcium channel blockers that were highly selective over L-type calcium channel blockers. Among the tested compounds, (+)-4-(3,5-dichloro-4-methoxy-phenyl)-1,4-dihydro-pyridine-3,5- dicarboxylic acid 3-cinnamyl ester was found to be an effective and selective N-type calcium channel blocker with oral analgesic potential.
