215169-00-9

Usage

Uses

Used in Pharmaceutical Industry:
(R)-2-(3-(3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)phenoxy)acetic acid is used as a potential pharmaceutical agent for its structural resemblance to known bioactive molecules, which may confer therapeutic benefits. Its specific application reasons and efficacy are yet to be determined through further research and development.
Given the complexity of the compound and the preliminary nature of the information provided, specific applications and industries have not been detailed beyond the general potential for pharmaceutical use. Further studies would be necessary to identify particular uses, such as in drug development for specific diseases or conditions, or in other industries where such a compound might have relevant applications.

Upstream product

• 178445-89-1 (R)-1-(3-(tert-butoxycarbonylmethoxy)phenyl)-3-(3,4-dimethoxyphenyl)-propan-1-ol 
• 215168-57-3 3,4-dimethoxy-3’-hydroxychalcone 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 178445-86-8 2[[3-(3,4-dimethyoxyphenyl)-1-oxopropyl]phenoxy]acetic acid 1,1-dimethylester 
• 178445-83-5 3-(3,4-dimethoxyphenyl)-1-(3-hydroxyphenyl)-1-propanone 
• 178445-80-2 (E)-1-(3,4-dimethoxyphenyl)-3-(3-hydroxyphenyl)prop-2-en-1-one 
• 121-71-1 3-Hydroxyacetophenone 

Downstream Products

• 1392284-65-9 C₄₄H₅₇N₃O₁₀ 
• 215169-01-0 (R,R)-1,10-bis[3-[3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy]-4,7-diaza-3,8-dioxadodecane 

Relevant academic research and scientific papers

PROTEIN-BINDING COMPOUNDS

The technology relates in part to compounds that bind to proteins. In certain examples, the compounds can bind to proteins that bind to rapamycin. In some examples, the compounds can bind to cellular proteins, and/or variant forms of cellular proteins, th

MULTIMERIC PIPERIDINE DERIVATIVES

The technology relates in part to compounds that bind to multimeric ligand binding regions, referred to herein as "multimeric compounds." In certain examples, the multimeric compounds provided herein bind to and multimerize polypeptides that bind to rimiducid, such as for example, chimeric polypeptides that comprise FKBP12 polypeptide variant regions. Multimeric compounds provided include those having a structure of Formula I. Where A, Z, Y, Z' and A' moieties are described herein.

METHODS AND COMPOSITIONS FOR THE SYNTHESIS OF MULTIMERIZING AGENTS

The invention features methods and compositions for the synthesis of multimerizing agents.

Synthesis and activity of bivalent FKBP12 ligands for the regulated dimerization of proteins

The total synthesis and in vitro activities of a series of chemical inducers of dimerization (CIDs) is described. The use of small-molecule CIDs to control the dimerization of engineered FKBP12-containing fusion proteins has been demonstrated to have broad utility in biological research as well as potential medical applications in gene and cell therapies. The facility and flexibility of preparation make this new class of wholly synthetic compounds exceptionally versatile tools for the study of intracellular signaling events mediated by protein-protein interactions or protein localization. While some congeners possess potency comparable to or better than the first generation natural product-derived CID, FK1012, structure-activity relationships are complex and underscore the need for application-specific compound optimizations. Copyright (C) 1998 Elsevier Science Ltd.