(R)-2-(3-(3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)phenoxy)acetic acid

Base Information

• Chemical Name: (R)-2-(3-(3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)phenoxy)acetic acid
• CAS No.: 215169-00-9
• Molecular Formula: C₁₉H₂₂O₆
• Molecular Weight: 346.38
• Mol file: 215169-00-9.mol

Synonyms:2-{3-[(1R)-3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy}acetic acid

Chemical Property of (R)-2-(3-(3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)phenoxy)acetic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(R)-2-(3-(3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)phenoxy)aceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-(3-(3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)phenoxy)acetic acid

There total 10 articles about (R)-2-(3-(3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)phenoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2[[3-(3,4-dimethyoxyphenyl)-1-oxopropyl]phenoxy]acetic acid 1,1-dimethylester (178445-86-8) → 2-{3-[(1R)-3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy}acetic acid (215169-00-9)

Guidance literature:

2[[3-(3,4-dimethyoxyphenyl)-1-oxopropyl]phenoxy]acetic acid 1,1-dimethylester; With B-chlorodiisopinocampheylborane; In tetrahydrofuran; at -35 - -25 ℃; for 6h; Inert atmosphere;

With water; sodium hydroxide; In methanol; for 1h;

With hydrogenchloride; In water; for 16h; pH=3;

Reference yield: 92.0%

(R)-1-(3-(tert-butoxycarbonylmethoxy)phenyl)-3-(3,4-dimethoxyphenyl)-propan-1-ol (178445-89-1) → 2-{3-[(1R)-3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy}acetic acid (215169-00-9)

Guidance literature:

With sodium hydroxide; In methanol; for 14h; Alkaline hydrolysis;

DOI:10.1016/S0968-0896(98)00125-4

Reference yield: 83.0%

C19H22N2O*C19H22O6 → 2-{3-[(1R)-3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy}acetic acid (215169-00-9)

Guidance literature:

With hydrogenchloride; In dichloromethane; water; at 20 ℃; for 1h;

upstream raw materials:

(R)-1-(3-(tert-butoxycarbonylmethoxy)phenyl)-3-(3,4-dimethoxyphenyl)-propan-1-ol

3-Hydroxyacetophenone

3,4-dimethoxy-benzaldehyde

(E)-1-(3,4-dimethoxyphenyl)-3-(3-hydroxyphenyl)prop-2-en-1-one

Downstream raw materials:

(R,R)-1,10-bis[3-[3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy]-4,7-diaza-3,8-dioxadodecane

C₄₄H₅₇N₃O₁₀