215171-87-2Relevant academic research and scientific papers
Chemically-tagged Mitsunobu reagents for use in solution-phase chemical library synthesis
Starkey, Gale W.,Parlow, John J.,Flynn, Daniel L.
, p. 2385 - 2390 (1998)
A general method for high-throughput product purification of Mitsunobu reactions is described. Tagged phosphine and azodicarboxylate reagents are used to synthesize individual library members in solution-phase. Workup and purification are easily accomplished by post-reaction sequestration of the tagged reagents and reagent byproducts by a complementary functionalized ion exchange resin. The reagents are utilized in a 3 step library synthesis.
