Bioorganic and Medicinal Chemistry Letters p. 2385 - 2390 (1998)
Update date:2022-07-30
Topics:
Starkey, Gale W.
Parlow, John J.
Flynn, Daniel L.
A general method for high-throughput product purification of Mitsunobu reactions is described. Tagged phosphine and azodicarboxylate reagents are used to synthesize individual library members in solution-phase. Workup and purification are easily accomplished by post-reaction sequestration of the tagged reagents and reagent byproducts by a complementary functionalized ion exchange resin. The reagents are utilized in a 3 step library synthesis.
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Doi:10.1016/S0040-4020(98)00775-3
(1998)Doi:10.1021/jo9814344
(1998)Doi:10.1016/0040-4020(73)80126-7
(1973)Doi:10.1016/S0022-328X(98)00739-6
(1998)Doi:10.1039/a805064c
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(1969)
