21520-79-6

Basic information

• Product Name: N-HYDROXY-1-HYDRAZINECARBOXAMIDE
• Synonyms: N-HYDROXY-1-HYDRAZINECARBOXAMIDE
• CAS NO: 21520-79-6
• Molecular Formula: CH₅N₃O₂
• Molecular Weight: 91.07
• Mol File: 21520-79-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 130-132°C
• Appearance: /
• Density: 1.493 g/cm³
• Refractive Index: 1.534
• CAS DataBase Reference: N-HYDROXY-1-HYDRAZINECARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-HYDROXY-1-HYDRAZINECARBOXAMIDE(21520-79-6)
• EPA Substance Registry System: N-HYDROXY-1-HYDRAZINECARBOXAMIDE(21520-79-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 21520-79-6(Hazardous Substances Data)

Usage

General Description

N-HYDROXY-1-HYDRAZINECARBOXAMIDE, also known as NHHC, is a chemical compound that is used in various industrial and scientific applications. It is commonly used as a crosslinking agent in the production of polymers, particularly in the manufacturing of resins and adhesives. NHHC is also used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Additionally, it is utilized in the production of dyes and pigments. NHHC is a potentially hazardous substance and proper precautions should be taken when handling and storing it, as it can be harmful if ingested or inhaled, and can cause skin and eye irritation.

InChI:InChI=1/CH5N3O2/c2-3-1(5)4-6/h6H,2H2,(H2,3,4,5)

Upstream product

• 35580-84-8 N-Hydroxy-carbamidsaeure-(2-hydroxyphenyl)-ester 
• 38064-07-2 phenyl N-hydroxycarbamate 
• 6294-89-9 hydrazinecarboxylic acid methyl ester 

Downstream Products

• 395639-32-4 1-(2,4-dihydroxybenzylidene)-4-hydroxysemicarbazide 
• 1344115-28-1 C₉H₁₁N₃O₃ 
• 1344115-27-0 C₈H₉N₃O₃ 
• 1344115-26-9 C₈H₉N₃O₃ 
• 1344115-29-2 C₉H₁₁N₃O₃ 

Relevant articles and documents

Chemical scaffolds with structural similarities to siderophores of nonribosomal peptide-polyketide origin as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis

Mycobacterium tuberculosis (Mtb) and Yersinia pestis (Yp) produce siderophores with scaffolds of nonribosomal peptide-polyketide origin. Compounds with structural similarities to these siderophores were synthesized and evaluated as antimicrobials against Mtb and Yp under iron-limiting conditions mimicking the iron scarcity these pathogens encounter in the host and under standard iron-rich conditions. Several new antimicrobials were identified, including some with increased potency in the iron-limiting condition. Our study illustrates the possibility of screening compound libraries in both iron-rich and iron-limiting conditions to identify antimicrobials that may selectively target iron scarcity-adapted bacteria and highlights the usefulness of building combinatorial libraries of compounds having scaffolds with structural similarities to siderophores to feed into antimicrobial screening programs.

Synthesis, biological evaluation, and quantitative structure -activity relationship analysis of new Schiff bases of hydroxysemicarbazide as potential antitumor agents

Thirty Schiff bases of hydroxysemicarbazide (Ar-CH=NNHCONHOH) have been synthesized and tested against L1210 murine leukemia cells. The IC50 values were found to be in a range from 2.7 × 10-6 to 9.4 × 10-4 M. A total of 17