215246-71-2

Upstream product

• 215246-66-5 2'-O-(t-butyldimethylsilyl)-7-deoxy-7β-thiopaclitaxel 
• 165065-01-0 2'-O-(t-butyldimethylsilyl)-7β-O-trifluoromethanesulfonyl-paclitaxel 
• 215246-62-1 2'-O-(t-butyldimethylsilyloxy)-7-deoxy-7α-thiopaclitaxel 
• 215246-59-6 2'-O-(t-butyldimethylsilyl)-7-deoxy-7α-acetylthio paclitaxel 

Relevant academic research and scientific papers

Synthesis of 7beta-sulfur analogues of paclitaxel utilizing a novel epimerization of the 7alpha-thiol group.

Paclitaxel analogues with a sulfur group at the 7beta position were required for SAR studies. Attempts to generate these compounds by displacing a 7alpha leaving group with sulfur nucleophiles were unsuccessful. Instead, these compounds were successfully