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2153-11-9 Usage


2'-CHLORO-4-HYDROXYACETANILIDE, also known as 4-(Chloroacetamido)phenol, is an organic compound that serves as a building block in the synthesis of various compounds. It is characterized by the presence of a chloroacetyl group attached to an aniline moiety, which provides it with unique chemical properties and reactivity.


Used in Pharmaceutical Industry:
2'-CHLORO-4-HYDROXYACETANILIDE is used as a building block for the synthesis of novel thiazolidinedione derivatives, which act as irreversible allosteric IKK-β modulators. These modulators play a crucial role in the development of new drugs targeting inflammatory and autoimmune diseases, as well as certain types of cancer.
Used in Chemical Synthesis:
2'-CHLORO-4-HYDROXYACETANILIDE is used as a key intermediate in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure allows for further functionalization and modification, making it a versatile starting material for the development of new molecules with potential applications in various industries.

Check Digit Verification of cas no

The CAS Registry Mumber 2153-11-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,5 and 3 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 2153-11:
49 % 10 = 9
So 2153-11-9 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017


1.1 GHS Product identifier

Product name 2-chloro-N-(4-hydroxyphenyl)acetamide

1.2 Other means of identification

Product number -
Other names 4-chloroacetamidophenol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2153-11-9 SDS

2153-11-9Relevant articles and documents

Design, synthesis and biological evaluation of novel thiazolidinedione derivatives as irreversible allosteric IKK-β modulators

Elkamhawy, Ahmed,Kim, Nam youn,Hassan, Ahmed H.E.,Park, Jung-eun,Yang, Jeong-Eun,Oh, Kwang-Seok,Lee, Byung Ho,Lee, Mi Young,Shin, Kye Jung,Lee, Kyung-Tae,Hur, Wooyoung,Roh, Eun Joo

, p. 691 - 704 (2018)

The kinase known as IKK-β activates NF-κB signaling pathway leading to expression of several genes contributing to inflammation, immune response, and cell proliferation. Modulation of IKK-β kinase activity could be useful for treatment and management of such diseases. Starting from a discovered weakly active hit compound, twenty four thiazolidinedione-scaffold based chemical entities belonging to five series have been designed, synthesized and evaluated as potential IKK-β modulators. Among them, compounds 6q, 6r and 6u showed low micromolar IC50 values while compounds 6v, 6w, and 6x elicited submicromolar IC50 values equal to 0.4, 0.7 and 0.9 μM respectively. These submicromolar IC50 values are 243, 139 and 105 folds the value of the reported IC50 of the starting hit compound. Kinetic study of compounds 6v and 6w confirmed this class of modulators as irreversible inhibitors. LPS-treated RAW 264.7 macrophages proved the anti-inflammatory activity of compounds 6q and 6v. Assay of hERG inhibition demonstrated a safe profile of compound 6q suggesting it as a lead for further development of IKK-β modulators.

Antidiabetic compounds


Page/Page column 13-14, (2020/06/16)

Compounds for the treatment of hyperglycemia and/or diabetes are provided. The compounds, which inhibit the enzyme dipeptidyl peptidase (DPP-4), are based on the structure where X may be present or absent an may be OH, Ar is an aryl group; and n ranges from 0 to 5.

Thiazolidine-2,4-dione-based irreversible allosteric IKK-β kinase inhibitors: Optimization into in vivo active anti-inflammatory agents

Elkamhawy, Ahmed,Kim, Nam youn,Hassan, Ahmed H.E.,Park, Jung-eun,Paik, Sora,Yang, Jeong-Eun,Oh, Kwang-Seok,Lee, Byung Ho,Lee, Mi Young,Shin, Kye Jung,Pae, Ae Nim,Lee, Kyung-Tae,Roh, Eun Joo

, (2019/12/30)

Selective kinase inhibitors development is a cumbersome task because of ATP binding sites similarities across kinases. On contrast, irreversible allosteric covalent inhibition offers opportunity to develop novel selective kinase inhibitors. Previously, we

Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and Stimulator for Interferon Genes (STING) modulators as cancer immunotherapeutics


Paragraph 0247; 0248, (2019/02/13)

Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.

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