21531-83-9Relevant academic research and scientific papers
Spectral, optical, and cytotoxicity studies on N-(2-isonicotinoylhydrazine-carbonothioyl)benzamide and its metal complexes
Hosny, Nasser Mohammed,Mahmoud, Heba M.,Abdel-Rhman, Mohamed H.
, (2018)
The ligand N-(2-isonicotinoylhydrazine-carbonothioyl)benzamide (H3L) and its metal complexes with Co(II), Ni(II), Cu(II), and Zn(II) acetates have been synthesized. The synthesized compounds have been characterized by elemental analyses, FT-IR,
Novel acyl thiourea derivatives: Synthesis, antifungal activity, gene toxicity, drug-like and molecular docking screening
Antypenko, Lyudmyla,Meyer, Fatuma,Kholodniak, Olena,Sadykova, Zhanar,Jirásková, Tereza,Troianova, Anastasiia,Buhaiova, Vladlena,Cao, Surui,Kovalenko, Sergiy,Garbe, Leif-Alexander,Steffens, Karl G.
, (2019)
Nine novel acyl thioureas were synthesized. Their identities and purities were confirmed by LC-MS spectra; each structure was elucidated by elemental analysis, IR, 1Н and 13C NMR spectra. Applying an in vitro screening of their antifungal potential, three substances (3, 5, and 6) could be selected as showing high activity against 11 fungi and 3 Phytophthora strains of phytopathogenic significance. Analysis of gene toxicity with the Salmonella reverse mutagenicity test, as an assessment of drug likeness, lipophilicity, and calculations of frontier molecular orbitals assign a low toxicity profile to these compounds. Molecular docking studies point to 14α-demethylase (CYP51) and N-myristoyltransferase (NMT) as possible fungal targets for growth inhibition. The findings are discussed with respect to structure–activity relationship (SAR).
Preparation of new 5-aroylamino substituted 3-nicotinoyl/isonicotinoyl-1,3,4-thiadiazol-2(3H)-ones with anti-inflammatory activity
Schenone, Silvia,Bruno, Olga,Ranise, Angelo,Bondavalli, Francesco,Filippelli, Walter,Falcone, Giuseppe,Piucci, Brunella,Sorrentino, Salvatore
, p. 586 - 589 (2007/10/03)
A series of 1,3,4-thiadiazol-2(3H)-ones (2a-j) with a nicotinoyl/isonicotinoyl group in position 3 and an aroylamino substituent in position 5 of the ring was prepared and evaluated for antipyretic and anti-inflammatory activities. All the title compounds
