215316-86-2Relevant academic research and scientific papers
New chiral hypervalent iodine compounds in asymmetric synthesis
Hirt, Urs H.,Spingler, Bernhard,Wirth, Thomas
, p. 7674 - 7679 (2007/10/03)
The synthesis of new chiral hypervalent iodine compounds 3 and their use in asymmetric oxidative functionalizations are described. The substituents in the chiral moiety and the stereoelectronic properties of the reagents 3, as well as the reaction conditions, have been optimized. Chiral hypervalent iodine compounds 3 have been investigated in the asymmetric dioxytosylation of styrène and in the a-oxytosylation of propiophenone as test reactions. X-ray structural analysis of some reagents shows an interaction between the chiral moiety and the iodine resulting in stereoselectivities up to 53% ee in the products.
