110718-87-1

Basic information

• Product Name: Ethanone, 1-(2-iodo-5-methoxyphenyl)-
• CAS NO: 110718-87-1
• Molecular Formula: C9H9IO2
• Molecular Weight: 276.074
• Mol File: 110718-87-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(2-iodo-5-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2-iodo-5-methoxyphenyl)-(110718-87-1)
• EPA Substance Registry System: Ethanone, 1-(2-iodo-5-methoxyphenyl)-(110718-87-1)

Safety Data

• Hazardous Substances Data: 110718-87-1(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(2-iodo-5-methoxyphenyl)- is a chemical compound with the molecular formula C9H9IO2. It is commonly referred to as 2-Iodo-5-methoxyacetophenone and is used in organic synthesis as an intermediate for the production of pharmaceuticals, dyes, and other fine chemicals. Ethanone, 1-(2-iodo-5-methoxyphenyl)- is a white to off-white solid at room temperature with a melting point of approximately 124-126 degrees Celsius. It is important to handle this compound with care as it is considered to be harmful if swallowed, inhaled, or in contact with skin and eyes.

Upstream product

• 54413-93-3 2-iodo-5-methoxybenzoic acid 
• 108-59-8 malonic acid dimethyl ester 
• 121-71-1 3-Hydroxyacetophenone 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 23042-77-5 1-(2-amino-5-methoxy-phenyl)-ethanone 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 75-05-8 acetonitrile 

Downstream Products

• 182320-30-5 2-(2-naphthyl)-5-methoxyphenylacetone 
• 153967-95-4 4-methoxy-2-vinylbenzoic acid 
• 1404432-59-2 1-iodo-4-methoxy-2-(prop-1-en-2-yl)benzene 
• 215317-12-7 (S)-bis(acetato-O)[2-(1-methoxyethyl)-4-methoxyphenyl]iodine 
• 215316-89-5 (S)-bis(acetato-O)[2-(1-methoxyethyl)-6-methoxyphenyl]iodine 
• 215317-02-5 (S)-2-iodo-5-methoxy-(1-methoxyethyl)benzene 
• 215316-86-2 (S)-2-iodo-3-methoxy-(1-methoxyethyl)benzene 
• 215316-80-6 (S)-1-(2-iodo-3-methoxyphenyl)ethanol 
• 23308-82-9 S-(-)-1-(3-methoxyphenyl)ethanol 
• 215316-97-5 (S)-1-(2-iodo-5-methoxyphenyl)ethanol 

Relevant articles and documents

Synthesis and antialgal activity of dihydrophenanthrenes and phenanthrenes II: Mimics of naturally occurring compounds in Juncus effusus

9,10-Dihydrophenanthrenes and phenanthrenes, mimics of natural compounds with strong antialgal activity, have been synthesized through cross-coupling by zerovalent Ni of 1-(2-iodo-5-methoxy)-phenylethanol or 2-iodo-5-methoxyacetophenone with iodoxylenes. The synthetic compounds had a hydroxyl or a methoxyl group at C-2 and two methyls in the C ring. Assays on the green alga Selenastrum capricornutum showed that all the compounds, except 2-methoxy-5,7-dimethylphenanthrene, caused strong inhibition of algal growth at 10-4 M. 2-Hydroxy-7,8-dimethyl-9,10-dihydrophenanthrene and 2-methoxy-5,6-dimethylphenanthrene fully inhibited growth at 10-5 M.

Palladium-Catalyzed Intermolecular [4+1] Spiroannulation by C(sp3)?H Activation and Naphthol Dearomatization

A novel palladium-catalyzed [4+1] spiroannulation was developed by using a C(sp3)?H activation/naphthol dearomatization approach. This bimolecular domino reaction of two aryl halides was realized through a sequence of cyclometallation-facilitat

Solvent directed electrophilic iodination and phenylselenenylation of activated alkyl aryl ketones

A mixture of molecular iodine and phenyliodine(III) bis(trifluoroacetate) (BTI) in CH3CN (or CH3OH) iodinates the aromatic ring of some activated alkyl aryl ketones. A different outcome results if PhSeSePh is used instead of I2