21535-05-7

Upstream product

• 22094-69-5 N-(4-methoxyphenyl)glycine 
• 5961-59-1 N-methyl-N-(4-methoxyphenyl)amine 
• 104-94-9 4-methoxy-aniline 
• 598-21-0 2-Bromoacetyl bromide 
• 22303-36-2 N-(4-methoxyphenyl)-2-chloroacetamide 
• 861366-40-7 N-(4-methoxy-phenyl)-N-[N-(4-methoxy-phenyl)-glycyl]-glycine 
• 71-43-2 benzene 
• 141-52-6 sodium ethanolate 

Downstream Products

• 861366-40-7 N-(4-methoxy-phenyl)-N-[N-(4-methoxy-phenyl)-glycyl]-glycine 
• 95693-57-5 1,4-bis(p-methoxyphenyl)-3-(2'-thiopyridyl)-6-(dimethylmalonyl)-2,5-piperazinedione (anti) 
• 95676-24-7 1,4-bis(p-methoxyphenyl)-3-(2'-thiopyridyl)-6-(dimethylmalonyl)-2,5-piperazinedione (syn) 
• 95676-13-4 1,4-bis(p-methoxyphenyl)-3,6-bis(2'-thiopyridyl)-2,5-piperazinedione 

Relevant academic research and scientific papers

The cytotoxic effects of diketopiperaizes against Leishmania donovani promastigotes and amastigotes

A series of diketopiperazine derivatives (1-12) were evaluated for their in vitro cytotoxic activity against Leishmania donovani promastigotes and amastigotes. Cytotoxicity study revealed that the number and types of the substituents in the phenyl rings h

Efficient synthesis of piperazinediones using potassium iodide catalysis in aqueous media

A simple and efficient synthetic approach to 1,4-disubstituted piperazine-2,5-diones was developed. A series of symmetrical 1,4-disubstituted piperazine-2,5-diones was prepared from chloroacetamides using potassium iodide catalysis in acetone/water. The structures of two products were confirmed by single crystal X-ray diffraction analysis.

Synthesis of symmetrically 1,4-disubstituted piperazine-2,5-diones: A new class of antileishmanial agents

A series of 1,4-diphenyl-2,5-dioxopiperazine derivatives were synthesised in one pot sequence. The compounds demonstrated appreciable cytotoxic activity against Leishmania donovani on both forms of the parasite, and the results suggested that some derivat

Divergent, Generalized Synthesis of Unsymmetrically Substituted 2,5-Piperasinediones

N,N'-Disubstituted 2,5-piperazinediones (12) can be 3,6-dibrominated followed by displacement with sodium 2-mercaptopyridine to furnish syn-1,4-disubstituted 3,6-bis(2'-thiopyridyl)-2,5-piperazinediones (8) in high yield.Precomplexation of these sulfides with silver(I) triflate followed by addition of trimethylsilyl enol ethers leads to chemoselective C-C bond formation, furnishing the homologated piperazinediones 10.The remaining sulfide functionality of 10 is relatively inert to a second substitution.These electrophylic 2,5-piperazinediones provide access to relatively inaccessible, unsymmetrical 2,5-piperazinediones and provide advantages over the corresponding well-known enolate anion approach.Substrates that contain N-p-methoxybenzyl residues can be deprotected to the lipophobic N,N'-unsubstituted 2,5-piperazinediones with aqueous ceric ammonium nitrate.The diastereoselectivity observed in the coupling reactions is discussed in the context of a single crystal X-ray structure determination of 20.