21535-44-4

Basic information

• Product Name: 6-Chloromethylmorphanthridine
• Synonyms: 6-(CHLOROMETHYL)-11H-DIBENZO[B,E]AZEPINE;6-CHLOROMETHYLMORPHANTHRIDINE;6-Chloromethylmorphenthridine
• CAS NO: 21535-44-4
• Molecular Formula: C₁₅H₁₂ClN
• Molecular Weight: 241.72
• Product Categories: Aromatics;Heterocycles;Intermediates
• Mol File: 21535-44-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 136-137 °C
• Boiling Point: 351.005 °C at 760 mmHg
• Flash Point: 166.082 °C
• Appearance: Off-White Solid
• Density: 1.19 g/cm³
• Vapor Pressure: 8.57E-05mmHg at 25°C
• Refractive Index: 1.625
• Solubility: Chloroform
• PKA: 3.35±0.20(Predicted)
• CAS DataBase Reference: 6-Chloromethylmorphanthridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloromethylmorphanthridine(21535-44-4)
• EPA Substance Registry System: 6-Chloromethylmorphanthridine(21535-44-4)

Safety Data

• Hazardous Substances Data: 21535-44-4(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Intermediate for Epinastine

Synthesis Reference(s)

Journal of Medicinal Chemistry, 13, p. 35, 1970 DOI: 10.1021/jm00295a010

InChI:InChI=1/C15H12ClN/c16-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)17-15/h1-8H,9-10H2

Upstream product

• 21535-43-3 N-[2-(phenylmethyl)phenyl]-2-chloroacetamide 
• 28059-64-5 2-benzylaniline 

Downstream Products

• 80012-43-7 epinastine 
• 706753-75-5 9H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine 
• 127786-29-2 3-amino-9,13b-dihydro-1H-dibenzimidazo<1,5-a>azepine hydrobromide 
• 127785-96-0 6,11-dihydro-5H-dibenzazepine-6-methanamine fumarate 
• 41218-84-2 6-aminomethyl-6,11-dihydro-5H-dibenzo[b,e]azepine 
• 74860-00-7 N-<(11H-dibenzazepin-6-yl)methyl>phthalimide 
• 642442-03-3 N-(11H-dibenzo[b,e]azepin-6-ylmethyl)-N-[(1'S)-1'-phenylethyl]amine 

Relevant articles and documents

Novel method of preparing Epinastine

The present invention relates to a novel manufacturing method for synthesizing an anti-histamine pharmaceutical medicine, epinastine. The novel manufacturing method for synthesizing epinastine according to the present invention has fewer synthesizing steps than a conventional epinastine manufacturing method, and is a safe synthesis method, thereby being expected to be used for inexpensively synthesizing the anti-histamine pharmaceutical medicine, epinastine by the manufacturing method, and supplying the same to the market.COPYRIGHT KIPO 2020

Preparation method of 6-Chloromethylmorphanthridine

The invention belongs to the technical field of medicinal chemistry and particularly relates to a preparation method of 6-Chloromethylmorphanthridine. The preparation method comprises the steps that under the action of concentrated sulfuric acid, N-[2-(phenyl methyl)phenyl]-2-chloroacetamide is taken as the raw material, a complex compound of a trifluoromethanesulfonic acid rare earth compound and dimethyl sulfoxide is taken as the catalyst, and dehydration cyclization is performed to prepare the 6-Chloromethylmorphanthridine. According to the preparation method of the 6-Chloromethylmorphanthridine, the complex compound of the trifluoromethanesulfonic acid rare earth compound and the dimethyl sulfoxide is taken as the catalyst, a better effect is realized, the pollution is small, the preparation method is environment-friendly, and recyclable production is realized.

Stereoselective synthesis of (R)-(-)-mianserin

(14bR)-2-Methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine, (R)-(-)-mianserin 1a was synthesised in several steps in good enantiomeric purity with the use of (S)-(-)-α-methylbenzylamine 5. The absolute configuration was assigned on the bas