215364-85-5

Usage

Uses

Used in Pharmaceutical Industry:
4-Amino-3-bromo-2-chloropyridine is used as a key intermediate in the synthesis of various biologically active substances, contributing to the development of new drugs and therapeutic agents. Its unique chemical structure allows for the creation of a wide range of pharmaceutical compounds with potential applications in treating various diseases and medical conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Amino-3-bromo-2-chloropyridine is utilized as a building block for the synthesis of agrochemicals, such as pesticides and herbicides. Its chemical properties enable the development of effective compounds that can protect crops from pests and diseases, thereby enhancing agricultural productivity and food security.
Safety Precautions:
Due to its harmful nature when swallowed, inhaled, or in contact with the skin, it is essential to handle 4-Amino-3-bromo-2-chloropyridine under controlled conditions to minimize health risks. Proper safety measures, including the use of personal protective equipment and adherence to safety protocols, should be implemented during its production, storage, and use.

InChI:InChI=1/C5H4BrClN2/c6-4-3(8)1-2-9-5(4)7/h1-2H,(H2,8,9)

Upstream product

• 14432-12-3 4-Amino-2-chloropyridine 

Downstream Products

• 952138-18-0 7-methoxy-1,4-dihydro-1,6-naphthyridin-4-one 
• 952138-17-9 8-bromo-7-methoxy-1,4-dihydro-1,6-naphthyridin-4-one 
• 952138-19-1 4-chloro-7-methoxy-[1,6]naphthyridine 
• 1418199-28-6 C₁₄H₁₇N₅ 
• 850180-82-4 3-bromo-2,4-dichloro-5-nitro-pyridine 
• 1268521-33-0 3-bromo-2-chloro-5-nitro-pyridin-4-ylamine 

Relevant academic research and scientific papers

GDF-8 INHIBITORS

Disclosed are 2,2'-bipyridyl compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein R1, Z and n are as described herein. In certain embodiments, a compound disclosed herein inhibits GDF8, and can be used to treat disease by blocking GDF8 signaling.

NOVEL NAPHTHYRIDINES AND ISOQUINOLINES AND THEIR USE AS CDK8/19 INHIBITORS

The present invention relates to naphthyridine and isoquinoline compounds, and pharmaceutically acceptable compositions thereof, useful as inhibitors of CDK8/19, and for the treatment of CDK8/19-related disorders.

Aurora Kinase Modulators and Method of Use

The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

AURORA KINASE MODULATORS AND METHOD OF USE

The present invention relates to chemical compounds having a general formula I {INSERT STRUCTURE HERE} wherein A1-8, D,, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

SPIROPIPERIDINE DERIVATIVES FOR CONTROLLING PESTS

The use of a compound of Formula (I), Y is a single bond, C=O, C=S or S(O)m where m is 0, 1 or 2; the ring represented by T is a 5 or 6 membered heteroaromatic and R1, R2, R3, R8 and Ra are specified organic groups and p is 0, 1, 2, 3, 4, 5 or 6; p+q is 1, 2, 3, 4, 5 or 6; or salts or N-oxides thereof or compositions containing them in controlling insects, acarines, nematodes or molluscs; novel compounds are also provided.