2154-24-7Relevant articles and documents
2-Pyrazolin-5-ones bearing a basic dialkylaminoalkyl substituent at the N1-position: Preparation and NMR spectroscopic investigations
Wolf, Barbara M.T.,Eller, Gernot A.,Holzer, Wolfgang
experimental part, p. 2035 - 2042 (2009/04/06)
2-Pyrazolin-5-ones (= tautomers to 5-hydroxypyrazols) bearing dialkylaminoyalkyl substituents at the ring nitrogen atom N-1 are prepared from the corresponding hydrazines and beta-ketoesters. Detailed NMR spectroscopic investigations (1H,
3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives: Inhibitors of immune complex induced inflammation
Haviv,Ratajczyk,DeNet,Kerdesky,Walters,Schmidt,Holms,Young,Carter
, p. 1719 - 1728 (2007/10/02)
3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives were evaluated in the dermal and pleural reverse passive Arthus reactions in the rat. In the pleural test these compounds were effective in reducing exudate volume and accumulation of white blood cells. This pattern of activity was similar to that of hydrocortisone and different from that of indomethacin. The structural requirements for inhibiting the Arthus reactions were studied by systematic chemical modification of 1. These structure-activity relationship studies revealed that nitrogen 1' of the hydrazino group is essential for activity and must be electron rich, whereas chemical modifications of other sites of 1 had only a modest effect on activity.