2154-34-9

Usage

Uses

Used in Organic and Polymer Chemistry:
TEMPO is used as a catalyst in the oxidation of alcohols to aldehydes and ketones, playing a crucial role in organic and polymer chemistry reactions. Its stability and reactivity contribute to its widespread use in these applications.
Used in Biological Studies:
In the field of biology, TEMPO is employed as a stable free radical probe, allowing researchers to study various biological processes and interactions involving free radicals.
Used in Electron Paramagnetic Resonance (EPR) Spectroscopy:
TEMPO also serves as a spin-label in EPR spectroscopy, a technique used to study the magnetic properties of molecules and the dynamics of molecular interactions.
Overall, [(2,2,5,5-Tetramethyl-3-oxo-pyrrolizino)oxy]radical, or TEMPO, is a multifaceted compound with applications in various industries, including chemical synthesis, biological research, and spectroscopic analysis. Its unique properties and reactivity make it an essential tool for advancing scientific understanding and developing new technologies.

Upstream product

• 5167-85-1 2,2,5,5-tetramethyl-3-oxopyrrolidine 
• 170642-05-4 1-Hydroxy-2,2,5,5-tetramethyl-pyrrolidin-3-one 
• 826-36-8 2,2,6,6-Tetramethyl-4-piperidone 
• 19805-75-5 2,2,5,5-tetramethyl-3-pyrroline-3-carboxamide 
• 117853-92-6 2,2,5-Trimethyl-1-oxy-2,4-dihydro-pyrrol-3-one 
• 57167-75-6 3,5-dibromo-2,2,6,6-tetramethylpiperidin-4-one 

Downstream Products

• 2154-37-2 3-hydroxy-2,2,5,5-tetramethylpyrrolidine-1-oxyl 
• 34272-83-8 2,2,5,5-tetramethyl-3-aminopyrrolidine-1-oxyl 
• 170642-05-4 1-Hydroxy-2,2,5,5-tetramethyl-pyrrolidin-3-one 
• 1227476-15-4 Azobenzene 
• 78097-44-6 C₂₄H₃₄N₆O₂ 
• 78097-45-7 C₂₈H₃₈N₆O₂ 

Relevant academic research and scientific papers

REACTION OF 2-SUBSTITUTED 5,5-DIMETHYL-4-OXO-1-PYRROLINE-1-OXIDES WITH NUCLEOPHILIC REAGENTS AND SYNTHESIS OF NITROXYL RADICALS - DERIVATIVES OF PYRROLIDINE

The reaction of β-oxonitrones, derivatives of pyrroline, with nitrogeneous nucleophiles and NaBH4 proceeds at the carbonyl group with the retention of the nitrone group.The reaction with organomagnesium and organolithium compounds takes place at the nitro

INFLUENCE OF CHEMICAL STRUCTURE OF NITROXYL SPIN LABELS ON THEIR REDUCTION BY ASCORBIC ACID

The influence of structure on the reduction of nitroxyl spin labels by ascorbic acid was examined using both piperidine and pyrrolidine nitroxyls.A five-fold molar excess of ascorbic acid and pH of 7.4 were used.The nitroxyl concentration was measured by electron spin resonance spectrometry.The five-membered (pyrrolidine) nitroxyls were more stable than the six-membered derivatives.Ring substituents also influenced the reaction.The anionic derivatives were more stable than the unionized compounds which, in turn, were more stable than the amines (cations at pH 7.4).

Nitroxydes 99: β-Cetoaldehydes nitroxydes et chelates metalliques correspondants a structure rigide. Synthese et etude spectroscopique

Syntheses and spectroscopic study of β-ketoaldehyde nitroxides and corresponding metal chelates (Copper II, Palladium II, and vanadyl) are described.The diamagnetic or paramagnetic nature of the complexed metal explains the various ESR spectra observed.A new route to 2,2,5,5-tetramethylpyrrolidin-3-one-1-yloxy, a nitroxide scarcely used so far in spite of its potentialities, is also described.